Association of Polymorphisms of F2 (rs3136520) and PAI-1(rs6090) Genes with Recurrent Pregnancy Loss in Iranian Azeri Women

Q4 Medicine

pzshkhy blyny bn syn Pub Date : 2021-09-01 DOI:10.52547/ajcm.28.2.118

M. Yousefian, S. Angaji, E. Siasi, S. Rahmani, Shamci Abbasalizadeh Khiaban

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引用次数: 0

Abstract

Background and Objective: The mutation of F2 and PAI-1 genes can cause thrombophilia in women. The present study aimed to assess the relationship of recurrent pregnancy loss (RPL) with rs3136520 in F2 and rs6090 in PAI-1. Materials and Methods: This case-control study was conducted on 120 women with idiopathic RPL as case group and 120 healthy women without any history of infertility or abortion with at least one healthy child as the control group. These subjects were referred to a private genetic lab by a gynecologist. Both polymorphisms were studied using the amplificationrefractory mutation system-polymerase chain reaction approach, and the obtained data were analyzed in SPSS software (version 26) using the chisquared test (P˂0.05). Results: In the multiplicative model, there was a significant association between rs6090 and RPL (OR=0.222; 95%CI=0.082-0.599); nonetheless, no relationship was detected between rs3136520 and RPL (OR=1, 95%CI=0.488-2.049). Moreover, according to additive model, there was no association between rs3136520 and RPL; however, there was a significant relationship between AG genotype in rs6090 and RPL (OR=0.245; 95%

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F2 (rs3136520)和PAI-1(rs6090)基因多态性与伊朗阿塞拜疆妇女复发性妊娠丢失的关系

背景与目的：F2和PAI-1基因突变可引起女性血栓形成倾向。本研究旨在评估复发性妊娠损失（RPL）与F2中rs3136520和PAI-1中rs6090的关系。材料和方法：本病例对照研究以120名特发性RPL妇女为病例组，120名无不孕或流产史的健康妇女为对照组，至少有一名健康儿童。这些受试者被一位妇科医生转介到一家私人基因实验室。结果：在乘法模型中，rs6090与RPL之间存在显著相关性（OR=0.222；95%CI=0.082-0.599）；但rs3136520与RPL无相关性（OR=1，95%CI=0.488-2.049）。此外，根据加性模型，rs313652与RPL之间无相关性；然而，rs6090中的AG基因型与RPL之间存在显著关系（OR=0.245；95%

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来源期刊

pzshkhy blyny bn syn

CiteScore

0.30

自引率

0.00%

发文量

审稿时长

8 weeks