Oral administration of 4′-demethyl nobiletin inhibits dry skin-induced mechanical alloknesis

Abstract

Mechanical alloknesis develops with dry skin and reduces the quality of life of people afflicted. Nobiletin (NOB) is a major citrus flavonoid with various health benefits. We investigated whether oral administration of NOB or 4’-demethyl NOB inhibits dry skin-induced alloknesis in a mouse model. As a result, both treatments were effective to inhibit mechanical alloknesis. These compounds may be promising candidates to lead to the development of therapeutic agents for mechanical alloknesis.