Pregnancy in thalassemia, anesthetic implication and perioperative management- A narrative review

IF 0.2 Q4 ANESTHESIOLOGY
Abhishek Singh, Karuna Sharma, V. Venkateswaran, A. Trikha
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引用次数: 0

Abstract

Advancement in the treatment of thalassemia has increased the life span of female patients, with the result that they are reaching the reproductive age group and expecting childbirth. Anesthesia is challenging in such patients due to ineffective erythropoiesis and multiple system involvement as a result of iron overload and chelation therapy. Careful management of the preconception phase, various conception strategies, and multidisciplinary management of pregnancy and childbirth can lead to a healthy and successful outcome of pregnancy. This review provides an overview of the pathophysiology and clinical manifestation of alpha and beta-thalassemia in pregnancy and its successful management. All available literature related to thalassemia was searched in major databases like PubMed, Embase, Scopus, and Google Scholar. Original articles, review articles, book chapters, guidelines, case reports, and correspondence were reviewed for pathophysiology, clinical manifestations, and anesthetic management of thalassemia during pregnancy with keywords like thalassemia, Cooley's anemia, thalassemia and pregnancy, anesthetic management of thalassemia, labor analgesia in thalassemia, and transfusion in thalassemia.
地中海贫血的妊娠、麻醉意义和围手术期管理——叙述性综述
地中海贫血治疗方面的进展延长了女性患者的寿命,使她们达到了生育年龄并准备分娩。由于铁超载和螯合治疗导致的红细胞生成无效和多系统受累,麻醉在这类患者中是具有挑战性的。仔细管理孕前阶段,各种受孕策略,以及多学科的妊娠和分娩管理可以导致一个健康和成功的妊娠结局。本文综述了妊娠期α和β -地中海贫血的病理生理和临床表现及其成功治疗。在PubMed、Embase、Scopus和谷歌Scholar等主要数据库中检索了所有与地中海贫血相关的文献。以地中海贫血、库利贫血、地中海贫血与妊娠、地中海贫血的麻醉管理、地中海贫血的分娩镇痛、地中海贫血的输血等为关键词,对妊娠期间地中海贫血的病理生理、临床表现、麻醉管理等方面的文章、综述文章、书籍章节、指南、病例报告、通信进行综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
自引率
0.00%
发文量
37
审稿时长
29 weeks
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