Combined Tumors in Hematolymphoid Neoplasms: Case Series of Histiocytic and Langerhans Cell Sarcomas Arising From Low-Grade B-Cell Lymphoma

IF 1.9 Q3 PATHOLOGY

Clinical Pathology Pub Date : 2019-01-01 DOI:10.1177/2632010X19878410

S. Skala, J. Ye, J. Stumph, W. Macon, Frances R Quinones, Vadim Khachaturov, R. Ketterling, R. Dewar

{"title":"Combined Tumors in Hematolymphoid Neoplasms: Case Series of Histiocytic and Langerhans Cell Sarcomas Arising From Low-Grade B-Cell Lymphoma","authors":"S. Skala, J. Ye, J. Stumph, W. Macon, Frances R Quinones, Vadim Khachaturov, R. Ketterling, R. Dewar","doi":"10.1177/2632010X19878410","DOIUrl":null,"url":null,"abstract":"We report an index case of histiocytic sarcoma arising in a 70-year-old patient with long-standing chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). The patient presented in 2017 with painful, enlarging swelling of the left neck. He had remote history of cutaneous squamous cell carcinoma with no sign of recurrence, and his CLL/SLL was thought to be in remission. Computed tomography showed mild splenomegaly and multifocal lymphadenopathy including a 3-cm left neck mass. Biopsy of the left neck mass showed CLL/SLL with associated histiocytic sarcoma. Flow cytometry demonstrated a B cell neoplasm with CLL/SLL phenotype. Despite radiation therapy, he expired 3 months after presentation. Two similar cases (CLL/SLL and histiocytic sarcoma, follicular lymphoma and Langerhans cell sarcoma) from another institution are also illustrated. The pathological features of combined tumors in lymphoid neoplasms, a general framework to the work-up to determine interrelatedness of tumor components, and the clinical relevance are discussed.","PeriodicalId":53204,"journal":{"name":"Clinical Pathology","volume":" ","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2632010X19878410","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Pathology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/2632010X19878410","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PATHOLOGY","Score":null,"Total":0}

引用次数: 5

Abstract

We report an index case of histiocytic sarcoma arising in a 70-year-old patient with long-standing chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). The patient presented in 2017 with painful, enlarging swelling of the left neck. He had remote history of cutaneous squamous cell carcinoma with no sign of recurrence, and his CLL/SLL was thought to be in remission. Computed tomography showed mild splenomegaly and multifocal lymphadenopathy including a 3-cm left neck mass. Biopsy of the left neck mass showed CLL/SLL with associated histiocytic sarcoma. Flow cytometry demonstrated a B cell neoplasm with CLL/SLL phenotype. Despite radiation therapy, he expired 3 months after presentation. Two similar cases (CLL/SLL and histiocytic sarcoma, follicular lymphoma and Langerhans cell sarcoma) from another institution are also illustrated. The pathological features of combined tumors in lymphoid neoplasms, a general framework to the work-up to determine interrelatedness of tumor components, and the clinical relevance are discussed.

查看原文本刊更多论文

血液淋巴肿瘤的合并肿瘤：低级别B细胞淋巴瘤引起的组织细胞和郎格罕细胞肉瘤病例系列

我们报告了一例70岁长期慢性淋巴细胞白血病/小淋巴细胞淋巴瘤（CLL/SLL）患者的组织细胞肉瘤指数病例。患者于2017年出现左颈部疼痛、肿胀加剧。他有皮肤鳞状细胞癌的病史，没有复发的迹象，他的CLL/SLL被认为处于缓解期。计算机断层扫描显示轻度脾肿大和多灶性淋巴结病，包括一个3厘米的左颈部肿块。左颈部肿块的活检显示CLL/SLL伴有相关的组织细胞肉瘤。流式细胞术显示B细胞肿瘤具有CLL/SLL表型。尽管接受了放射治疗，他还是去世了演示后数月。还说明了来自另一个机构的两个类似病例（CLL/SLL和组织细胞肉瘤、滤泡性淋巴瘤和郎格汉斯细胞肉瘤）。讨论了淋巴肿瘤中合并肿瘤的病理特征、确定肿瘤成分相关性的一般框架以及临床相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical Pathology PATHOLOGY-

CiteScore

2.20

自引率

7.70%

发文量