Pharmacological evaluation of Prosopis ruscifolia extract on lipid profile in hyperglycemic and hyperlipidemic mice

Q3 Agricultural and Biological Sciences
J. Centurión, E. Diarte, A. Galeano, María S. Soverina, W. Arrua, M. L. Kennedy, M. A. Campuzano-Bublitz
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引用次数: 0

Abstract

Diabetes is a serious chronic pathology, with long-term effects including damage to blood vessels or diabetic dyslipidemia. Diabetic dyslipidemia is characterized by increasing concentrations of low-density triglycerides and lipoproteins and a decrease in high-density lipoproteins HDL-cholesterol (HDL-c). This study aimed to evaluate the effect of Prosopis ruscifolia on lipid profile in albino Swiss mice with hyperglycemia and hyperlipidemia. Hyperglycemia was induced by alloxan and the animals were orally treated with Pr (50, 100, and 200 mg/kg) for 45 days. Hyperlipidemia was induced with tyloxapol and the animals were treated with Pr (50, 100, and 200 mg/kg). In hyperglycemic animals treated with 100 mg/kg, there was a decrease in the concentration of cholesterol, a decrease in the concentration of triglycerides, and an increase in HDL-c at the end of treatment compared to untreated hyperglycemic animals. In mice with hyperlipidemia treated with 50 and 100 mg/kg of Pr, serum cholesterol and triglyceride concentration were reduced. HDL-c increased in animals treated with Pr 50, 100, and 200 mg/kg compared to untreated animals. It was observed that the administration of P. ruscifolia in hyperglycemic and hyperlipidemic animals had a favorable effect on the lipid profile.
山茱萸提取物对高血糖和高脂血症小鼠血脂的药理学评价
糖尿病是一种严重的慢性疾病,其长期影响包括血管损伤或糖尿病血脂异常。糖尿病血脂异常的特征是低密度甘油三酯和脂蛋白浓度增加,高密度脂蛋白HDL-胆固醇(HDL-c)降低。本研究旨在评估俄罗斯前列素对患有高血糖和高脂血症的白化瑞士小鼠脂质代谢的影响。四氧嘧啶诱导高血糖,并用Pr(50、100和200mg/kg)口服治疗动物45天。用tyloxapol诱导高脂血症,并用Pr(50、100和200mg/kg)治疗动物。在用100mg/kg治疗的高血糖动物中,与未经治疗的高糖动物相比,治疗结束时胆固醇浓度降低,甘油三酯浓度降低,HDL-c增加。在用50和100mg/kg Pr治疗的高脂血症小鼠中,血清胆固醇和甘油三酯浓度降低。与未治疗的动物相比,用Pr 50、100和200mg/kg治疗的动物HDL-c增加。观察到,在高血糖和高脂血症动物中施用鲁西福立雅对脂质分布有有利的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Applied Biology and Biotechnology
Journal of Applied Biology and Biotechnology Agricultural and Biological Sciences-Food Science
CiteScore
1.80
自引率
0.00%
发文量
181
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