{"title":"Gastrointestinal Symptoms and Hepatopancreatic Involvement in COVID-19 Children: A Narrative Review","authors":"S. Mehrabani, M. Nikpour, L. Moslemi","doi":"10.32598/jpr.10.specialissue.344.2","DOIUrl":null,"url":null,"abstract":"Background: To the best of our knowledge, limited studies explored gastrointestinal (GI) symptoms and hepatopancreatic involvement in children with coronavirus disease 2019 (COVID- 19) infection. Objectives: This review study aimed to evaluate the GI symptoms and abnormal liver and pancreas function in children with COVID-19 infection. Methods: In this review study, databases of Scopus, PubMed, Google Scholar, and Web of Science were searched using the relevant keywords of “COVID-19,” “children,” “gastrointestinal,” “liver,” and “pancreas.” Descriptive and cross-sectional studies were reviewed in the current study, with the main focus on GI symptoms and elevated liver enzymes in children with COVID-19 infection. Results: Overall, 27 studies from countries of Iran, Spain, Turkey, Italy, and the United States were selected. Although the prevalence of GI symptoms varied in different studies, our review showed that most children with COVID-19 infection experienced GI symptoms. In addition to GI symptoms, there is the possibility of elevated liver enzymes, such as alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and creatine phosphokinase in children with COVID-19 infection. Conclusions: COVID-19 infection may present various GI, hepatic, and pancreatic manifestations in children. The difference in the prevalence of these symptoms can probably be attributed to the geographical region of the study and the history of the disease.","PeriodicalId":43059,"journal":{"name":"Journal of Pediatrics Review","volume":" ","pages":""},"PeriodicalIF":0.3000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pediatrics Review","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32598/jpr.10.specialissue.344.2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 1
Abstract
Background: To the best of our knowledge, limited studies explored gastrointestinal (GI) symptoms and hepatopancreatic involvement in children with coronavirus disease 2019 (COVID- 19) infection. Objectives: This review study aimed to evaluate the GI symptoms and abnormal liver and pancreas function in children with COVID-19 infection. Methods: In this review study, databases of Scopus, PubMed, Google Scholar, and Web of Science were searched using the relevant keywords of “COVID-19,” “children,” “gastrointestinal,” “liver,” and “pancreas.” Descriptive and cross-sectional studies were reviewed in the current study, with the main focus on GI symptoms and elevated liver enzymes in children with COVID-19 infection. Results: Overall, 27 studies from countries of Iran, Spain, Turkey, Italy, and the United States were selected. Although the prevalence of GI symptoms varied in different studies, our review showed that most children with COVID-19 infection experienced GI symptoms. In addition to GI symptoms, there is the possibility of elevated liver enzymes, such as alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and creatine phosphokinase in children with COVID-19 infection. Conclusions: COVID-19 infection may present various GI, hepatic, and pancreatic manifestations in children. The difference in the prevalence of these symptoms can probably be attributed to the geographical region of the study and the history of the disease.
背景:据我们所知,有限的研究探讨了2019冠状病毒病(COVID- 19)感染儿童的胃肠道(GI)症状和肝胰腺的损害。目的:本回顾性研究旨在评估COVID-19感染儿童的胃肠道症状和肝胰功能异常。方法:以“COVID-19”、“儿童”、“胃肠道”、“肝脏”、“胰腺”等相关关键词检索Scopus、PubMed、谷歌Scholar和Web of Science数据库。本研究回顾了描述性和横断面研究,主要关注COVID-19感染儿童的胃肠道症状和肝酶升高。结果:总的来说,来自伊朗、西班牙、土耳其、意大利和美国的27项研究被选中。尽管胃肠道症状的患病率在不同的研究中有所不同,但我们的综述显示,大多数感染COVID-19的儿童都出现了胃肠道症状。除了胃肠道症状外,COVID-19感染儿童还可能出现肝酶升高,如丙氨酸转氨酶、天冬氨酸转氨酶、乳酸脱氢酶和肌酸磷酸激酶。结论:儿童COVID-19感染可能出现多种胃肠道、肝脏和胰腺表现。这些症状患病率的差异可能归因于研究的地理区域和疾病史。