Are Antipyretic Medications Compatible with SARS-CoV-2 Vaccines?

Abstract

Vaccine hesitancy is an issue that should be addressed to maximize protection from serious COVID-19. SARSCoV-2 vaccination hesitancy in the United States ranges from 21 to 42%.[1] Fear of adverse effects and concerns about safety are some of the main reasons for refusing to be immunized.[2, 3] Vaccinations can induce adverse reactions, such as injection site tenderness, headache, myalgia, and arthralgia. Fever is occasionally a systemic side effect.[4] People often self-treat these problems with antipyretic and/or analgesic drugs; physicians sometimes recommend these as well.