Effects of Dietary Supplementation with High-Dose Choline Alfoscerate (Cerebrain® Forte) on Cognitive Functioning in Patients with Minor Neurocognitive Disorder (Mind): A Pilot Study

Abstract

Effects of Dietary Supplementation with High-Dose Choline Alfoscerate (Cerebrain Forte) on Cognitive Functioning in Patients with Minor Neurocognitive Disorder (Mind): A Pilot Study. J Abstract Introduction and aim of the study: Normal and pathological aging have been related to deficits of several neurotransmitters able to account for cognitive, emotional and behavioral disorders associated with mild cognitive decline or overt dementia. Among the neurotransmitter deficits involved in cognitive disorders, with particular reference to those underlying memory and attentional functions, the cholinergic one is certainly the main one [1]. This justified the treatment of these disorders with drugs and supplements capable of enhancing cholinergic transmission by inhibiting the degradation of acetylcholine (acetylcholinesterase inhibitors) or by increasing the production of the neurotransmitter through the exogenous supply of precursors [2,3]. Choline Alfoscerate is at the forefront of these supplements. The effect of the supplements is dose-dependent, and it is therefore likely that a high-dose formulation is associated with effects on cognition of a higher entity than that with medium or medium-low dosages. Aim of this pilot study is to evaluate the effects of dietary supplementation