Protective Effect of Heteroxenia Fuscescens Extract Against Sodium Arsenite-Induced Infertility in Male Rats

Q2 Pharmacology, Toxicology and Pharmaceutics

Current Bioactive Compounds Pub Date : 2023-08-15 DOI:10.2174/1573407219666230815105059

A. Mohamed, A. Omar, Basma Soliman, A. Dakrory, M. Al-Hammady

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引用次数: 0

Abstract

Arsenic is a potent environmental toxin with dangerous effects on human and animal populations. Heteroxenia fuscescens (H. fuscescens) extract exhibits potential health effects. The purpose of this study was to assess the protective effect of H. fuscescens extract against sodium arsenite-induced infertility and toxicity in rats Forty male rats were separated into four groups as follows: control group (2% DMSO, orally), sodium arsenite (10 mg/kg, orally), sodium arsenite + H. fuscescens extract (60 mg/kg in 2% DMSO), and H. fuscescens extract (60 mg/kg in 2% DMSO). GC/MS analysis of H. fuscescens indicates the presence of 10 compounds at retention times of 6.00, 12.53, 19.04, 24.60, 28.56, 35.66, 38.99, 45.29, 48.02, and 52.14. fuscescens extract improves levels of sperm count (53.33 ± 1.52), motility (43.00 ± 1.10), FSH ( 2.17 ± 0.04), LH (2.43 ± 0.06), testosterone (1.87 0.02), and testis weight (0.49 ± 0.01). The antioxidant activity of H. fuscescens extract was reported by a significant decrease in MDA (1.02 ± 0.01) and NO (520.39 ± 14.99) levels, while it significantly increased levels of GSH (1.77 ± 0.07), and CAT (71.38 ± 3.45). Histopathological alterations of the testes, liver, and kidney observed with sodium arsenite have been improved in the treatment group. Heteroxenia fuscescens is beneficial in restoring male sex hormone levels, maintaining a healthy sperm profile, and reducing oxidative stress, all of which lead to an improvement in male rat fertility.

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褐花花提取物对亚砷酸钠致雄性大鼠不育的保护作用

砷是一种强效环境毒素，对人类和动物种群具有危险影响。fuscescens (H. fuscescens)提取物具有潜在的健康作用。为了研究褐花花提取物对亚砷酸钠致大鼠不孕症的保护作用和毒性作用，将40只雄性大鼠分为4组:对照组(2% DMSO，口服)、亚砷酸钠(10 mg/kg，口服)、亚砷酸钠+褐花花提取物(60 mg/kg, 2% DMSO)和褐花花提取物(60 mg/kg, 2% DMSO)。GC/MS分析表明，褐梭菌中含有10种化合物，保留时间分别为6.00、12.53、19.04、24.60、28.56、35.66、38.99、45.29、48.02和52.14。梭香提取物可提高精子数(53.33±1.52)、活力(43.00±1.10)、FSH(2.17±0.04)、LH(2.43±0.06)、睾酮(1.87 0.02)和睾丸质量(0.49±0.01)。黄花楸提取物抗氧化活性显著降低MDA(1.02±0.01)和NO(520.39±14.99)水平，显著提高GSH(1.77±0.07)和CAT(71.38±3.45)水平。用亚砷酸钠观察到的睾丸、肝脏和肾脏的组织病理学改变在治疗组得到改善。fuscescenia在恢复雄性性激素水平、维持健康的精子特征和减少氧化应激方面是有益的，所有这些都导致雄性大鼠生育能力的提高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Bioactive Compounds Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

1.90

自引率

0.00%

发文量

112

期刊介绍： The journal aims to provide comprehensive review articles on new bioactive compounds with proven activities in various biological screenings and pharmacological models with a special emphasis on stereoeselective synthesis. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia. The journal should prove to be essential reading for pharmacologists, natural product chemists and medicinal chemists who wish to be kept informed and up-to-date with the most important developments on new bioactive compounds of natural or synthetic origin, including their stereoeselective synthesis.