Partial Atrophy of The Pancreas in Endoscopic Ultrasonography may be a Sign of Pancreatic Cancer

Abstract

Methods: Records of patients with pancreatic lesions were retrospectively assessed. EUS findings, serum C19-9 levels, CEA levels, and cyst biochemistry of the patients were noted. The relationship between PC, mucinous pathologies, EUS findings, cyst characteristics, and serum biochemistry was evaluated. Results: Two-hundred-four patients had EUS-guided biopsy for a pancreatic lesion (48% solid). Eighty-nine patients had PC. The serum CA19-9 cut-off value for PC was 37 U/mL (AUC: 0.81). In multivariate analysis, solid lesions, age, CA19-9>37 U/mL, and partial atrophy in the pancreas were independently associated with PC. For solid lesions, age and size >24 mm; and for cystic lesions, male gender and mucinous pathology were independently associated with PC. Thirty-six of the cystic lesions had mucinous pathology. Cyst and serum CEA, string sign, wesung connection