The Influence of 6-Shogaol, a Therapeutic Agent of Zingiber Officinale, on the Interaction of Ciprofloxacin with Bovine Serum Albumin

IF 1.4 Q3 CHEMISTRY, MULTIDISCIPLINARY
Mohaddeseh Bahramian-Nasab, Fatemeh S. Mohseni‐Shahri
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引用次数: 1

Abstract

The binding of ciprofloxacin (CIP) to bovine serum albumin (BSA) in the existence and absence of 6-shogaol was investigated by multiple techniques. Fluorescence spectroscopy results indicated that CIP was able to be quenching of BSA without and with 6-shogaol by way of a static mechanism. The CIP and 6-shogaol binding to BSA leads to the increase of the binding constant (Ka) value of CIP to BSA. In accordance with the minus amounts of ΔH0 and ΔS0, the functions of hydrogen bond and van der Waals forces are very important all over this special binding. In addition, the minus amounts of ΔH0 and ΔS0 for BSA-CIP in the existence of 6-shogaol have been larger than those of the absence of 6-shogaol, which illustrates the higher importance of hydrogen bonding and van der Waals forces. As indicated by the synchronized fluorescence spectroscopy at Δλ = 60 nm, the location of CIP with mixed BSA in binary and trinary systems has been nearer to Tyr residues.
生姜治疗药物6-Shogaol对环丙沙星与牛血清白蛋白相互作用的影响
采用多种方法研究了在有无6-巯基的条件下,环丙沙星(CIP)与牛血清白蛋白(BSA)的结合。荧光光谱结果表明,CIP能以静态机制对BSA进行猝灭。CIP和6-巯基与BSA的结合导致CIP与BSA结合常数(Ka)值的增加。根据ΔH0和ΔS0的负值,氢键和范德华力的函数在整个特殊结合中都非常重要。此外,在存在6-shogaol的情况下,BSA-CIP的ΔH0和ΔS0的负值大于不存在6-shogol的情况下的ΔH0和ΔS0,这说明氢键和范德华力的重要性更高。如Δλ=60nm处的同步荧光光谱所示,在二元和三元系统中,具有混合BSA的CIP的位置更接近Tyr残基。
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来源期刊
Physical Chemistry Research
Physical Chemistry Research CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
2.70
自引率
8.30%
发文量
18
期刊介绍: The motivation for this new journal is the tremendous increasing of useful articles in the field of Physical Chemistry and the related subjects in recent years, and the need of communication between Physical Chemists, Physicists and Biophysicists. We attempt to establish this fruitful communication and quick publication. High quality original papers in English dealing with experimental, theoretical and applied research related to physics and chemistry are welcomed. This journal accepts your report for publication as a regular article, review, and Letter. Review articles discussing specific areas of physical chemistry of current chemical or physical importance are also published. Subjects of Interest: Thermodynamics, Statistical Mechanics, Statistical Thermodynamics, Molecular Spectroscopy, Quantum Chemistry, Computational Chemistry, Physical Chemistry of Life Sciences, Surface Chemistry, Catalysis, Physical Chemistry of Electrochemistry, Kinetics, Nanochemistry and Nanophysics, Liquid Crystals, Ionic Liquid, Photochemistry, Experimental article of Physical chemistry. Mathematical Chemistry.
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