Radiation induced mucositis and its relationship with nutritional status in head and neck cancer patients treated with radiotherapy

Q4 Nursing

中华临床营养杂志 Pub Date : 2019-12-30 DOI:10.3760/CMA.J.ISSN.1674-635X.2019.06.007

Lichuan Zhang, Yujie Wang, B. Zhuang, Hongmei Li, L. Gong, Yanli Wang, Yu Fang, Yan Sun, S. Xiao, B. Zheng

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引用次数: 0

Abstract

Objective To describe the characteristics of radiation induced mucositis in patients with head and neck cancer (HNC) during radiotherapy, and analyze the effect of radiation induced mucositis on diet patterns and weight change and the influencing factors for radiation induced mucositis. Methods Patients with HNC treated with radiotherapy in one cancer hospital were recruited. Data were collected before, during and at the end of the radiotherapy, which included radiation induced oral and pharyngeal mucositis, pain during eating, diet patterns and weight. Results Two hundred and two patients were completely investigated and 43.5% and 34.2% of the patients suffered from moderate to severe(≥grade 2) oral mucositis and pharyngeal mucositis, respectively during the radiotherapy. At the end of radiotherapy, 53.5% and 51.5% of the patients suffered from moderate to severe oral mucositis and pharyngeal mucositis (≥grade 2), respectively. Oral and pharyngeal mucositis were significantly correlated with pain during eating, diet patterns and weight(P<0.05). Tumor site was the main reason that affected the severity of mucositis(Wald χ2=26.033, 14.216; P<0.001). Conclusion Radiation induced mucositis was gradually aggravated with radiotherapy progress, which is closely related to pain during eating, change of diet patterns and weight loss. The severity of mucositis is related to the tumor site. Measures should be taken to strengthen the management of adverse reactions and nutritional status of patients. Key words: Head and Neck Cancer; Radiation Induced Mucositis; Pain; Diet Pattern; Weight

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癌症放疗后头颈部放射性粘膜炎及其与营养状况的关系

目的探讨癌症头颈部放疗过程中放射性粘膜炎的特点，分析放射性粘膜炎对饮食结构、体重变化的影响及影响因素。方法选择癌症某医院接受放射治疗的HNC患者。在放射治疗之前、期间和结束时收集数据，包括放射诱导的口腔和咽部粘膜炎、进食过程中的疼痛、饮食模式和体重。结果对222例患者进行了全面的调查，放疗中口腔黏膜炎和咽黏膜炎的发生率分别为43.5%和34.2%。放疗结束时，53.5%和51.5%的患者分别患有中重度口腔粘膜炎和咽粘膜炎（≥2级）。口咽粘膜炎与进食疼痛、饮食方式和体重显著相关（P<0.05）。肿瘤部位是影响粘膜炎严重程度的主要原因（Waldχ2=26.033，14.216；P<0.001），改变饮食模式和减肥。粘膜炎的严重程度与肿瘤部位有关。应采取措施加强对患者不良反应和营养状况的管理。关键词：癌症；辐射引起的粘膜炎；疼痛；饮食模式；重量

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来源期刊

中华临床营养杂志 Nursing-Nutrition and Dietetics

CiteScore

0.20

自引率

0.00%

发文量

2282

期刊介绍： The Chinese Journal of Clinical Nutrition was founded in 1993. It is the first professional academic journal (bimonthly) in my country co-sponsored by the Chinese Medical Association and the Chinese Academy of Medical Sciences to disseminate information on clinical nutrition support, nutrient metabolism, the impact of nutrition support on outcomes and "cost-effectiveness", as well as translational medicine and nutrition research. It is also a professional journal of the Chinese Medical Association's Parenteral and Enteral Nutrition Branch. The purpose of the Chinese Journal of Clinical Nutrition is to promote the rapid dissemination of knowledge on nutrient metabolism and the rational application of parenteral and enteral nutrition, focusing on the combination of multidisciplinary and multi-regional field investigations and clinical research. It mainly reports on nutritional risk screening related to the indications of parenteral and enteral nutrition support, "cost-effectiveness" research on nutritional drugs, consensus on clinical nutrition, guidelines, expert reviews, randomized controlled studies, cohort studies, glycoprotein and other nutrient metabolism research, systematic evaluation of clinical research, evidence-based case reports, special reviews, case reports and clinical experience exchanges, etc., and has a special column on new technologies related to the field of clinical nutrition and their clinical applications.