Design of Novel MgZrO3@Fe2O3@ZnO as a Core-Shell Nano Catalyst: An Effective Strategy for the Synthesis of Pyranopyrazole Derivatives

Abstract

Catalysis has been widely applied in pharmaceutical companies in recent years. This paper reports a useful new approach for the synthesis of pyranopyrazoles. One-pot synthesis of pyranopyrazoles using MgZrO3@Fe2O3@ZnO as a novelcore–shell nanocatalyst which increases reaction rate, selectivity, ease of work-up and recyclability of the supports. Method: The present study deals with the synthesis of MgZrO3@Fe2O3@ZnO core-shell catalyst using the sol-gel method. To develop the new catalytic reaction The synthesized MgZrO3@Fe2O3@ZnO core-shell nanoparticles were analysed using XRD, TEM and BET surface area. The nanocatalyst had an average particle size of 20 nm by TEM images and BET Surface area of 58.93 m2/g. Novel MgZrO3@Fe2O3@ZnO core-shell nanoparticles have been used as an efficient and recoverable catalyst for one-pot synthesis of pyranopyrazoles. Using a sol-gel approach, we have developed a facile synthesis pathway for MgZrO3@Fe2O3@ZnO core–shell nanoparticles. In conclusion, herein we report first time a new application of novel MgZrO3@Fe2O3@ZnO for the synthesis of pyranopyrazole using one-pot four component reaction of hydrazine hydrate, ethyl acetoacetate (EAA), malononitrile, and different aromatic aldehydes in ethanol. The salient features of this methodology includes use of small amount of MgZrO3@Fe2O3@ZnO catalyst, good yield ,easy operation, short reaction , time separation of catalyst from reaction medium and recyclability of catalyst . the importance of this methodology is the use of environmentally benign catalyst and avoid hazardous organic catalyst. Finally, use of recyclable catalyst can save substantially reduce solvent and energy usage during the recovery process.