Intravenous buprenorphine does not impair psychomotor and cognitive functioning in opioid-dependent patients using oral dextropropoxyphene: A randomized, double-blind, crossover study

IF 0.6 Q4 PSYCHIATRY
S. Goyal, A. Ambekar, R. Jain, M. Mehta, A. Mishra
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引用次数: 0

Abstract

Background and Objectives: Some opioid-dependent injecting buprenorphine (BPN) users can continue to inject BPN even while using dextropropoxyphene as a treatment or as a drug of abuse. With this rationale, this study was aimed to assess the effect of injection BPN on psychomotor and cognitive functioning in opioid-dependent patients receiving oral dextropropoxyphene. Methods: This was a randomized, placebo-controlled, double-blind, crossover study, carried out in the inpatient unit of the tertiary level de-addiction facility. Twenty opioid-dependent male, current injecting drug users were given a single dose of injection of BPN (1.2 mg) or placebo, in a crossover design, 2 h after the routine morning dose of oral dextropropoxyphene at day 4 and day 6 of admission. Psychomotor and cognitive functioning was assessed with the help of standard tools (trail making – Parts A and B, digit symbol substitution test, delayed recall test, and digit span) at baseline and after 10 min, 3 h, and 6 h of injection BPN/placebo. Results: There was no significant difference in the scores on any of the tests for psychomotor and cognitive functioning at any time period after receiving either injection BPN or placebo. Conclusions: A single dose of intravenous BPN in opioid-dependent patients on oral dextropropoxyphene did not produce any significant change in psychomotor and cognitive functioning as compared to placebo.
静脉注射丁丙诺啡不会损害口服右丙氧芬阿片类药物依赖患者的精神运动和认知功能:一项随机、双盲、交叉研究
背景和目的:一些阿片类药物依赖性注射丁丙诺啡(BPN)使用者即使在使用右丙氧芬作为治疗或滥用药物的同时,也可以继续注射BPN。基于这一原理,本研究旨在评估注射BPN对口服右丙氧芬的阿片类药物依赖患者的心理运动和认知功能的影响。方法:这是一项随机、安慰剂对照、双盲、交叉研究,在三级戒毒机构的住院单元进行。在入院第4天和第6天,20名阿片类药物依赖的男性、目前的注射吸毒者在常规口服右丙氧芬早晨剂量后2小时,以交叉设计的方式接受单剂量BPN(1.2 mg)或安慰剂注射。在基线和注射BPN/安慰剂10分钟、3小时和6小时后,借助标准工具(线索制作——A和B部分、数字符号替代测试、延迟回忆测试和数字跨度)评估心理运动和认知功能。结果:在接受注射BPN或安慰剂后的任何时间段,精神运动和认知功能的任何测试得分都没有显著差异。结论:与安慰剂相比,口服右丙氧芬的阿片类药物依赖患者单剂量静脉注射BPN不会对精神运动和认知功能产生任何显著变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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审稿时长
31 weeks
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