Inherited and modifiable factors need to be identified in young patients with atrioventricular block

Abstract

Atrioventricular block (AVB) is among the leading diagnoses requiring pacemaker implantation. The incidence of this cardiac conduction disorder increases with age: from the UK Biobank, a community-dwelling cohort of approximately half a million participants, conduction disorders were far more present in those ≥65 years of age versus under the age of 55 (55/10.000 vs 11/10.000, respectively). 1 AVB is defined as delayed or interrupted impulse conduction and can be caused by anatomical or func-tional disorders of the conduction system. An extrinsic or physiological AVB can be secondary to increased parasympathetic tone, and is often self- limiting and does not require therapy. Intrinsic or pathological AVB is subdivided into suprahisian and infrahisian, the being predominantly benign and the requiring is referred The main is the conduction elder