Effects of vitamin D supplementation on glycaemic control and lipid profiles in gestational diabetes mellitus: a Meta-analysis of randomized controlled trials

Q4 Nursing

中华临床营养杂志 Pub Date : 2019-08-30 DOI:10.3760/CMA.J.ISSN.1674-635X.2019.04.003

Yu Bai, Lei Tang

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引用次数: 0

Abstract

Objective To systematically evaluate the effects of vitamin D supplementation on glucose homeostasis parameters and lipid profiles in gestational diabetes patients. Methods Four main databases including PubMed, Web of Science, CNKI and Wanfang were searched to collect randomized controlled trials (RCTs) about vitamin D supplementation for gestational diabetes mellitus from inception to February 1, 2018.Two investigators were chosen to search, extract and evaluate the data independently. Software RevMan 5.3 and Stata 15.0 were used for meta-analysis. Results Results A total of 6 randomized RCTs were included including 409 patients totally which were divided into two groups as study group(n=204) and control group(n=205). The results showed that compared with the control group, patients in study group had lower fasting plasma glucose(FPG)[MD=-11.43, 95% CI=(-15.24-7.61), P=0.000 01], fasting insulin(FIns)[MD=-4.8, 95% CI=(-5.99, 3.62), P<0.000 01], insulin homeostasis model assessment of insulin resistance(HOMA-IR)[MD=-1.48, 95% CI=(-1.81, 1.16), P<0.000 01], total-cholesterol(TC)[MD=-14.09, 95% CI=(-22.09, 5.2), P=0.002], low-density lipoprotein(LDL)[MD=-10.54, 95% CI=(-18.18, 2.89), P=0.007] and high-density lipoprotein(HDL)[MD=2.11, 95% CI=(0.36, 3.86), P=0.02]. No significant difference was found in triglycerides level(TG) between the two groups. Conclusion Vitamin D supplementation in patients with gestational diabetes can improve FPG, insulin, TC, LDL, insulin resistance and HDL, but has no effect on TG. Key words: Vitamin D; Gestational diabetes mellitus; Meta-analysis; Randomized controlled trials

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补充维生素D对妊娠期糖尿病患者血糖控制和血脂的影响:一项随机对照试验的荟萃分析

目的系统评价补充维生素D对妊娠期糖尿病患者葡萄糖稳态参数及血脂的影响。方法检索PubMed、Web of Science、CNKI、万方等4大数据库，收集2018年2月1日至2018年2月1日有关补充维生素D治疗妊娠期糖尿病的随机对照试验(rct)。选择两名调查人员独立搜索、提取和评估数据。meta分析采用软件RevMan 5.3和Stata 15.0。结果共纳入6项随机对照试验，共纳入409例患者，分为研究组(n=204)和对照组(n=205)。结果显示，与对照组相比，研究组患者空腹血糖(FPG)[MD=-11.43, 95% CI=(-15.24-7.61)， P= 0.0001]，空腹胰岛素(FIns)[MD=-4.8, 95% CI=(-5.99, 3.62)， P< 0.0001]，胰岛素稳态模型胰岛素抵抗评估(HOMA-IR)[MD=-1.48, 95% CI=(-1.81, 1.16)， P< 0.0001]，总胆固醇(TC)[MD=-14.09, 95% CI=(-22.09, 5.2)， P=0.002]，低密度脂蛋白(LDL)[MD=-10.54, 95% CI=(-18.18, 2.89)]，P=0.007]和高密度脂蛋白(HDL)[MD=2.11, 95% CI=(0.36, 3.86)， P=0.02]。两组间甘油三酯水平(TG)无显著差异。结论妊娠期糖尿病患者补充维生素D可改善FPG、胰岛素、TC、LDL、胰岛素抵抗和HDL，但对TG无影响。关键词:维生素D;妊娠期糖尿病;荟萃分析;随机对照试验

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来源期刊

中华临床营养杂志 Nursing-Nutrition and Dietetics

CiteScore

0.20

自引率

0.00%

发文量

2282

期刊介绍： The Chinese Journal of Clinical Nutrition was founded in 1993. It is the first professional academic journal (bimonthly) in my country co-sponsored by the Chinese Medical Association and the Chinese Academy of Medical Sciences to disseminate information on clinical nutrition support, nutrient metabolism, the impact of nutrition support on outcomes and "cost-effectiveness", as well as translational medicine and nutrition research. It is also a professional journal of the Chinese Medical Association's Parenteral and Enteral Nutrition Branch. The purpose of the Chinese Journal of Clinical Nutrition is to promote the rapid dissemination of knowledge on nutrient metabolism and the rational application of parenteral and enteral nutrition, focusing on the combination of multidisciplinary and multi-regional field investigations and clinical research. It mainly reports on nutritional risk screening related to the indications of parenteral and enteral nutrition support, "cost-effectiveness" research on nutritional drugs, consensus on clinical nutrition, guidelines, expert reviews, randomized controlled studies, cohort studies, glycoprotein and other nutrient metabolism research, systematic evaluation of clinical research, evidence-based case reports, special reviews, case reports and clinical experience exchanges, etc., and has a special column on new technologies related to the field of clinical nutrition and their clinical applications.