Lipid Profile Status in Chronic Obstructive Pulmonary Disease and its Association with Disease Severity

Abstract

Introduction: Dyslipidemia is considered as the major risk factor for cardiovascular disease (CVD) and may contribute to the higher mortality in chronic obstructive pulmonary disease (COPD). However, the prevalence and consequences of dyslipidemia in COPD is still unclear. Aims: We studied comprehensive lipid profile panel including serum total cholesterol (TC), triglyceride (TG), low density lipoproteins (LDL), very low-density lipoproteins (VLDL) and high-density lipoproteins (HDL) in COPD patients to study the relationship of dyslipidemia with severity of disease. Methods: Serum TC, TG, LDFL, VLDL and HDL were measured at baseline patients with COPD. Anthropometry including BMI, mid upper arm circumference (MUAC), sum of four skin fold thickness and six-minute walk test (6MWT) were done in all the patients. Results: Of 125 recruited patients, 35 had moderate, 52 severe & 38 very severe COPD. Total cholesterol in moderate, severe and very severe COPD was 178.5 ± 34.5 mg/dl, 174.2 ± 36.4 and 169.4 ± 34.1 mg/dl respectively. Level of LDL in moderate, severe and very severe COPD was 107.5 ± 34.5 mg/dl, 103.0 ± 33.7 & 103.1 ± 35.6 mg/dl respectively. HDL levels in moderate, severe & very severe COPD were 43.2 ± 5.3, 44.9 ± 8.4, 43.1 ± 9.5 mg/dl. VLDL levels in moderate, severe and very severe COPD were 21.0 (11.0-112.0), 21.9 (2.0-177.0), 21.0 (10.0-80.0) mg/dl. TG levels in moderate, severe & very severe COPD was 106.0 (55.0-418.0), 106.0 (36.0-353.0), 103.0 (52.0-295.00 mg/dl respectively. 6MWT, BMI & MUAC decreased with severity of COPD. There was no significant difference in smoking index and waist hip ratio in the 3 groups. Conclusions: We did not find any correlation between COPD disease severity and lipoproteins.