AGP Related Evaluation of Medical Nutrition Therapy for Diabetes Management (AMEND) – A Real World Observation Study

Abstract

Purpose: To evaluate 24 hour glycaemic profile using AGP in patients with type 2 diabetes who are eligible for meal replacement therapy over a period of 14 days. To assess whether a precise meal replacement plan as an add on to standard of care will make a difference in smoothening out post-prandial peaks and increasing time spent in the desired (70 mg/dl-180 mg/dl) range compared to baseline time in range and post-prandial blood glucose level. Methods: Patients were mounted with AGP asked to follow the regular diet for 6 days. On the 7 th day, based on the AGP report, the most troubled meal was replaced with protein rich, calorie counted, low-carb and fiber enriched meal supplement for the next 6 days. On day 14, the AGP data were collected. Results: The analysis of full cohort (n=566) showed reduction in eA1c and eAG by 11.9% (from 7.84% to 6.90%) and 15.10% (from 178.41 mg/dL to 151.47 mg/dL), respectively when regular meal diet was compared with the replaced meal diet. The average TIR was improved by 23.56% (from 41.38 to 51.13) in full cohort, post-intervention with replaced meal. Conclusion: The glycemic profile of patients with type 2 diabetes was improved by meal replacement therapy over period of 14 days.