Effects of Intra-Dialysis Resistance Training in Hemodynamic Parameters, Oxidative Stress and Health-Related Quality of Life in Patients with Chronic Kidney Disease

Abstract

Purpose: Chronic kidney disease is a public health problem that causes severe complications to the patient. The major damage is the loss of muscle mass, with a consequent reduction in the functional capacity that is associated with hypertension and increased oxidative stress. This study aimed to evaluate the effect of intra-dialysis resistance training on the hemodynamic parameters, oxidative stress and quality of life in patients with chronic kidney disease. Methods: The volunteers underwent a physical training during the hemodialysis sessions. The hemodynamic parameters, oxidative stress, the quality of life, the functional autonomy and one repetition maximum (1 RM) were evaluated. Results: The data did not show alterations in the hemodynamic parameters, nitric oxide or lipid peroxidation after 12 weeks of resistance training. We observed significant differences in the quality of life in the following dimensions of the Kidney Disease Quality of Life Short Form (KDQOL-SFTM) questionnaire after 12 weeks of resistance training: Functional capacity, physical aspects, vitality, social and emotional aspects and mental health (P < 0.05). The time needed to execute the functional autonomy test was improved after the resistance training, and strength was increased significantly in all the exercises, as assessed by the 1 RM test (P < 0.001). Conclusion: In conclusion, after 12 weeks, the intra-dialysis resistance training did not modify the hemodynamic parameters neither the oxidative stress profile of these patients, but improved their quality of life. These data show that intra-dialysis resistance training is safe and can provide many physical and emotional benefits to chronic kidney disease patients.