Green Synthesis and Anti-microbial Activities of Some Thiazole-imino Derivatives

IF 0.7 Q4 CHEMISTRY, MULTIDISCIPLINARY

Orbital: The Electronic Journal of Chemistry Pub Date : 2023-07-11 DOI:10.17807/orbital.v15i2.17611

Satbir Singh, S. Raj, Sunil V Sharma, Sucheta, V. Yadav

引用次数: 1

Abstract

The ring forming reaction of furfural imine (A) and substituted acetophenone (B) via a greener approach resulted in the synthesis of thiazole-imino derivatives (C1 – C5). The compound A was synthesized by green method using acetic acid in aqueous media where conc. Sulfuric acid was avoided. The final compounds (C1-C5) were again synthesized in aqueous media avoiding use of organic solvents. The resultant compounds were characterized and distinguished from their precursors by elemental analysis, 1H-NMR, 13C-NMR and IR spectral studies. The in-vitro activities of the final compounds (C1-C5) depicted that they are all appreciably active against bacterial strains S. aureus, B. subtilis and fungal strains C. albicans, C. glabrata. Ciprofloxacin and Itraconazole were used as the control drugs for anti-bacterial and for anti-fungal activities; respectively. As compared to the other analogues, compound C2 (R = NO2) and C4 (R = Cl) showed best activities against the bacterial and fungal strains; respectively.

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噻唑亚胺衍生物的绿色合成及其抗菌活性

糠醛亚胺（A）和取代的苯乙酮（B）通过更环保的方法进行成环反应，合成了噻唑亚胺衍生物（C1–C5）。以乙酸为原料，在水性介质中，用绿色法合成了化合物A。避免使用硫酸。最终的化合物（C1-C5）再次在避免使用有机溶剂的水性介质中合成。通过元素分析、1H-NMR、13C-NMR和IR光谱研究对所得化合物进行了表征，并将其与前体进行了区分。最终化合物（C1-C5）的体外活性表明，它们都对细菌菌株金黄色葡萄球菌、枯草芽孢杆菌和真菌菌株白色念珠菌、光滑念珠菌具有明显的活性。环丙沙星和伊曲康唑作为抗菌和抗真菌活性的对照药物；分别地与其他类似物相比，化合物C2（R=NO2）和C4（R=Cl）对细菌和真菌菌株表现出最好的活性；分别地

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来源期刊

Orbital: The Electronic Journal of Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

10 weeks

期刊介绍： Orbital: The Electronic Journal of Chemistry is a quarterly scientific journal published by the Institute of Chemistry of the Universidade Federal de Mato Grosso do Sul, Brazil. Original contributions (in English) are welcome, which focus on all areas of Chemistry and their interfaces with Pharmacy, Biology, and Physics. Neither authors nor readers have to pay fees. The journal has an editorial team of scientists drawn from regions throughout Brazil and world, ensuring high standards for the texts published. The following categories are available for contributions: 1. Full papers 2. Reviews 3. Papers on Education 4. History of Chemistry 5. Short communications 6. Technical notes 7. Letters to the Editor The Orbital journal also publishes a number of special issues in addition to the regular ones. The central objectives of Orbital are threefold: (i) to provide the general scientific community (at regional, Brazilian, and worldwide levels) with a formal channel for the communication and dissemination of the Chemistry-related literature output by publishing original papers based on solid research and by reporting contributions which further knowledge in the field; (ii) to provide the community with open, free access to the full content of the journal, and (iii) to constitute a valuable channel for the dissemination of Chemistry-related investigations.