The link between IL-6 rs2069840 SNP and cancer risk: Evidence from a systematic review and meta-analysis

IF 0.8 Q4 GENETICS & HEREDITY

Meta Gene Pub Date : 2021-12-01 DOI:10.1016/j.mgene.2021.100972

Md. Abdul Barek , Mobashera Begum , Furhatun Noor , Md. Abdul Aziz , Mohammad Safiqul Islam

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引用次数: 3

Abstract

Cancer is the second leading global health burden in terms of incidence and mortality. The association between IL-6 rs2069840 variant and cancer risk has been evaluated previously by genome-wide association studies and case-control studies, but the results remained controversial. Our present meta-analysis aimed to reveal the association of IL-6 rs2069840 polymorphism with cancer risk for the first time. Review Manager 5.4 software was used for performing the meta-analysis, and heterogeneity was assessed using I². A total of 13 retrospective studies with 22,487 cases and 26,540 controls were selected for performing this meta-analysis. Our study showed that rs2069840 is not significantly associated with overall cancer risk. After stratification with population subgroups, no relationship was observed in Asians, Caucasians, Africans, or mixed populations. Subgroup analyses based on the cancer types revealed a significant correlation of rs2069840 with breast cancer in COD3 (OR = 1.13, p = 0.008), RM (OR = 1.10, p = 0.023), and OD (OR = 0.94, p = 0.029). A significant correlation was also found in COD1 (OR = 1.08, p = 0.020) and OD (OR = 1.07, p = 0.022) models for the development of other cancers (multiple myeloma, prostate cancer, gastric cancer). The findings of the present study suggest that IL-6 rs2069840 polymorphism is not linked with overall cancer risk. However, this polymorphism may be associated with breast cancer, multiple myeloma, prostate cancer, and gastric cancer.

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IL-6 rs2069840 SNP与癌症风险之间的联系:来自系统评价和荟萃分析的证据

就发病率和死亡率而言，癌症是全球第二大健康负担。IL-6 rs2069840变异与癌症风险之间的关系此前已通过全基因组关联研究和病例对照研究进行了评估，但结果仍存在争议。本荟萃分析旨在首次揭示IL-6 rs2069840多态性与癌症风险的关系。采用Review Manager 5.4软件进行meta分析，采用I2评估异质性。本次荟萃分析共纳入13项回顾性研究，共纳入22487例病例和26540例对照。我们的研究表明rs2069840与总体癌症风险没有显著相关性。在对人群亚群进行分层后，在亚洲人、高加索人、非洲人或混合人群中未观察到相关性。基于癌症类型的亚组分析显示，rs2069840与乳腺癌的COD3 (OR = 1.13, p = 0.008)、RM (OR = 1.10, p = 0.023)和OD (OR = 0.94, p = 0.029)具有显著相关性。COD1 (OR = 1.08, p = 0.020)和OD (OR = 1.07, p = 0.022)模型与其他癌症(多发性骨髓瘤、前列腺癌、胃癌)的发展也存在显著相关性。本研究的结果表明，IL-6 rs2069840多态性与总体癌症风险无关。然而，这种多态性可能与乳腺癌、多发性骨髓瘤、前列腺癌和胃癌有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Meta Gene Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： Meta Gene publishes meta-analysis, polymorphism and population study papers that are relevant to both human and non-human species. Examples include but are not limited to: (Relevant to human specimens): 1Meta-Analysis Papers - statistical reviews of the published literature of human genetic variation (typically linked to medical conditionals and/or congenital diseases) 2Genome Wide Association Studies (GWAS) - examination of large patient cohorts to identify common genetic factors that influence health and disease 3Human Genetics Papers - original studies describing new data on genetic variation in smaller patient populations 4Genetic Case Reports - short communications describing novel and in formative genetic mutations or chromosomal aberrations (e.g., probands) in very small demographic groups (e.g., family or unique ethnic group). (Relevant to non-human specimens): 1Small Genome Papers - Analysis of genetic variation in organelle genomes (e.g., mitochondrial DNA) 2Microbiota Papers - Analysis of microbiological variation through analysis of DNA sequencing in different biological environments 3Ecological Diversity Papers - Geographical distribution of genetic diversity of zoological or botanical species.