Guía clínica. Fármacos antiepilépticos de elección para crisis focales y generalizadas en adultos

Abstract

The mainstay of treatment in patients with epilepsy is the use of antiepileptic drugs (AEDs). Currently, there are a significant number of AEDs in Mexico. For the pharmacological management of the patient with epilepsy, it is important to know the pharmacokinetics, dosage, mechanism of action, and formulations of the AEDs. 70-80% of patients with either focal or generalized seizures are completely seizure free on AED monotherapy. When, despite the use of AED in monotherapy, seizure freedom is not achieved, a second AED should be used; AEDs with different mechanisms of action are empirically combined el 100% de control; sin embargo, es importante considerar que de un 20 a un 30% no logra esta meta 3 .