Synthesis of Tetrahydrobenzo[b]pyrans Promoted by Sodium Stearate as a Lewis Base-Surfactant Combined Catalyst in an Aqueous Micellar Medium

Abstract

The use of green catalysts is one of the most crucial elements in the greening of synthetic chemical processes. In line with this, current research initiatives in our lab have concentrated on the creation of green catalysts 1 – 4 for organic synthesis. Surfactant molecules can group together in an aqueous phase under ambient conditions to create micelles, which have a hydrophobic core and a hydrophilic corona. The widespread and in-depth study of micellar surfactants as catalysts for various reactions in aqueous solutions opens the door for more synthesis methods using aqueous media. Sodium stearate is a common surfactant found in frequently-used preparations. However, there are not many studies on organic reactions using sodium stearate as a catalyst. 5 In this context, we present below a straightforward and effective technique for the synthesis of tetrahy-drobenzo[ b ]pyrans using a Lewis base-surfactant-combined (LBSC) catalyzed three-component one-pot reaction in an aqueous micellar medium. Pyrans have such noteworthy pharmacological characteristics (Figure 1) as Chk1 kinase inhibitory, 6 analgesic, 7 anticancer, 8 vasodilatory, 9 antihypertensive, hepatoprotective, cardiotonic, 10 vasodilator, 11 anti-leukemic, 12,13 emetic, 14 anti-anaphylactic, 15 diuretic 16 and anti-Alzheimer 17 properties. Many