Simultaneous detection of molecules with the surface-enhanced infrared absorption sensor platform based on disk antennas with double spacer

IF 1.1 4区 化学 Q3 SPECTROSCOPY
Ahmet Murat Erturan, H. Durmaz, S. S. Gültekin
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引用次数: 0

Abstract

Abstract Biomolecule detection has become important in many applications such as medical diagnosis, forensic analysis, basic biological studies, and food quality assessment. In particular, the Mid-infrared range offers an important opportunity for biomolecular sensing as it covers the molecular vibrational spectra of vital biochemicals such as Deoxyribonucleic acid, Ribonucleic Acid, and proteins. In this study, a double band absorbing plasmonic nanoantenna array with two gold disk resonators is proposed. The biosensing ability of this structure was investigated using the protein-goat anti-mouse immunoglobulin G model and Polymethyl methacrylate film. The basic structural bonds of protein monolayer, namely Amide-I, Amide-II, and Amide-III showed vibrational signatures at 6010 nm (∼1664 cm−1), 6496 nm (∼1539 cm−1), and 6989 nm (∼1431 cm−1) wavelengths, respectively. In addition, the spectral response of the proposed antenna structure was investigated using a Polymethyl methacrylate film by detecting the C=O and the C-H bonds. The strong dipole moment at C=O showed a strong absorption deep at 5782 nm (∼1730 cm−1) while the C-H bond has shown a relatively low absorption deep at 3350 nm (∼2985 cm−1) and 3395 nm (∼2946 cm−1). Our findings indicate that the double spacer disk configuration detects the spectral signature of the protein monolayer and Polymethyl methacrylate film in each band, simultaneously. The dual-band can be tuned independently by carefully engineering the radii of the double disks without making an effect on the other band. The proposed structure can be used as a characterization tool for identifying unknown complex molecules by simply detecting their spectral fingerprints in each mode of the dual-band, independently. Also, this design strategy can be insight to multi-mode SEIRA platforms, where more complex chemical molecules are needed to be detected or identified in biology, chemistry, and defense areas.
基于双间隔圆盘天线的表面增强红外吸收传感器平台的分子同步检测
摘要生物分子检测在医学诊断、法医学分析、基础生物学研究和食品质量评估等领域具有重要应用。特别是,中红外范围为生物分子传感提供了一个重要的机会,因为它涵盖了脱氧核糖核酸、核糖核酸和蛋白质等重要生物化学物质的分子振动光谱。在本研究中,提出了一种具有两个金盘谐振器的双频带吸收等离子体纳米天线阵列。利用山羊抗小鼠免疫球蛋白G模型和聚甲基丙烯酸甲酯薄膜研究了该结构的生物传感能力。蛋白质单层的基本结构键,即酰胺-I、酰胺II和酰胺III,在6010处显示出振动特征 纳米(~1664 cm−1),6496 纳米(~1539 cm−1)和6989 纳米(~1431 cm−1)波长。此外,通过检测C=O和C-H键,使用聚甲基丙烯酸甲酯薄膜研究了所提出的天线结构的光谱响应。C=O处的强偶极矩在5782处表现出强烈的深吸收 nm(~1730 cm−1),而C-H键在3350深处显示出相对较低的吸收 纳米(~2985 cm−1)和3395 纳米(~2946 cm−1)。我们的发现表明,双间隔盘结构同时检测到每个带中蛋白质单层和聚甲基丙烯酸甲酯膜的光谱特征。双波段可以通过仔细设计双圆盘的半径进行独立调谐,而不会对另一个波段产生影响。所提出的结构可以用作鉴定未知复杂分子的表征工具,只需独立地检测它们在双频带的每个模式中的光谱指纹。此外,这种设计策略可以深入了解多模式SEIRA平台,在生物学、化学和国防领域需要检测或识别更复杂的化学分子。
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来源期刊
Spectroscopy Letters
Spectroscopy Letters 物理-光谱学
CiteScore
2.90
自引率
5.90%
发文量
50
审稿时长
1.3 months
期刊介绍: Spectroscopy Letters provides vital coverage of all types of spectroscopy across all the disciplines where they are used—including novel work in fundamental spectroscopy, applications, diagnostics and instrumentation. The audience is intended to be all practicing spectroscopists across all scientific (and some engineering) disciplines, including: physics, chemistry, biology, instrumentation science, and pharmaceutical science.
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