Progress on haploidentical hematopoietic stem cell transplantation

国际输血及血液学杂志 Pub Date : 2019-11-20 DOI:10.3760/CMA.J.ISSN.1673-419X.2019.06.008

Yuan-yuan Feng, Jianyong Li

引用次数: 0

Abstract

Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is a reliable, effective and emerging treatment for hematological malignancies.Due to the difficulty of human leukocyte antigen (HLA) matching between donors and recipients, the One-child policy, and the decrease of HLA-matched sibling donor (MSD) and so on, the donors selection is greatly limited in hematopoietic stem cell transplant(HSCT). This article reviews the new researches on clinical outcomes for different hematological diseases, conditioning regimen and the prophylaxis of graft versus host disease (GVHD) in the context of haplo-HSCT. Key words: Hematopoietic stem cell transplantation; Leukemia; Transplantation conditioning; Graft vs host disease; Haploidentical hematopoietic stem cell transplantation

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单倍体造血干细胞移植研究进展

单倍体造血干细胞移植（haplo-HSCT）是一种可靠、有效且新兴的治疗血液系统恶性肿瘤的方法。由于供受者之间的人类白细胞抗原（HLA）匹配困难、独生子女政策以及HLA匹配兄弟供体（MSD）的减少等原因，造血干细胞移植（HSCT）中供体的选择受到很大限制。本文综述了在haplo-HSCT背景下对不同血液系统疾病的临床结果、调理方案和移植物抗宿主病（GVHD）预防的最新研究。关键词：造血干细胞移植；白血病；移植条件；移植物抗宿主病；单倍体造血干细胞移植

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

国际输血及血液学杂志

自引率

0.00%

发文量

10610

期刊介绍： The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.