I. V. Smolyaninov, D. A. Burmistrova, N. P. Pomortseva, A. I. Poddel’sky, N. T. Berberova
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引用次数: 0
Abstract
Novel thioethers with nitrogen- and oxygen-containing heterocyclic moieties and a redox-active catechol group were synthesized. The radical scavenging and antioxidant activities of the compounds were studied in reactions with synthetic radicals and in the DNA oxidative damage. The catechols with nitrogen-containing heterocyclic substituents or a furan ring showed pronounced radical scavenging activity in reactions with diphenylpicrylhydrazyl or generated 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation. In the case of DNA oxidative damage, a dual anti/pro-oxidant effect was found. Catechol thioethers with methoxybenzoxazole or furan rings showed the highest activity in all biological assays.
期刊介绍：
Doklady Chemistry is a journal that publishes new research in chemistry and chemical engineering of great significance. Initially the journal was a forum of the Russian Academy of Science and published only best contributions from Russia in the form of short articles. Now the journal welcomes submissions from any country in the English or Russian language. Every manuscript must be recommended by Russian or foreign members of the Russian Academy of Sciences.
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