Prognostic value of the fibrinogen to albumin ratio in patients with gallbladder carcinoma

中华普通外科杂志 Pub Date : 2020-02-25 DOI:10.3760/CMA.J.ISSN.1007-631X.2020.00.015

Rui Li, Shibo Song, Qiang Li, Xiaolei Shi, Zhen Sun, Xiu-wen He, Zhe Li, Jinghai Song

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Abstract

Objective To investigate the prognostic value of preoperative fibrinogen and albumin ratio (FAR) in patients with gallbladder carcinoma. Methods The clinicopathological data of 100 patients with gallbladder carcinoma who underwent radical surgery at Beijing Hospital from Feb 2007 to Feb 2019 were retrospectively analyzed. The receiver operating characteristic (ROC) curve was drawn to determine the optimal cut-off value of FAR, and the prognostic factors were evaluated by Kaplan-Meier method, univariate and multivariate analysis. Results The optimal cut-off value of preoperative FAR for postoperative overall survival was 0.08. FAR was significantly associated with preoperative total bilirubin(TBil)levels, tumor differentiation, T stage, TNM stage, resection margin status, and preoperative CA199 levels (all P<0.05). Multivariate analysis indicated that TNM staging (HR=3.562, 95% CI: 1.075-11.798, P=0.038) and FAR (HR=2.482, 95% CI: 1.263-4.875, P=0.008) were independent prognostic factors in patients with gallbladder carcinoma who underwent radical surgery. Conclusion Preoperative FAR is closely related to the prognosis of patients with gallbladder carcinoma and might be useful for the evaluation of prognosis of patients with gallbladder carcinoma. Key words: gallbladder carcinoma; fibrinogen; albumin; prognosis

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纤维蛋白原与白蛋白比值对胆囊癌患者的预后价值

目的探讨胆囊癌患者术前纤维蛋白原与白蛋白比值（FAR）对预后的价值。方法回顾性分析2007年2月至2019年2月在北京医院行胆囊癌根治术的100例胆囊癌患者的临床病理资料。绘制受试者工作特性（ROC）曲线以确定FAR的最佳临界值，并通过Kaplan-Meier法、单变量和多变量分析评估预后因素。结果术前FAR对术后总生存率的最佳临界值为0.08。FAR与术前总胆红素（TBil）水平、肿瘤分化程度、T分期、TNM分期、切缘状态、，多因素分析表明，TNM分期（HR=3.562，95%CI:1.075-11.798，P=0.038）和FAR（HR=2.482，95%CI:1.263-4.875，P=0.008）是胆囊癌根治性手术患者的独立预后因素。结论术前FAR与胆囊癌患者的预后密切相关，可用于评估胆囊癌患者预后。关键词：胆囊癌；纤维蛋白原；白蛋白；预后

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中华普通外科杂志

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