Survival analysis and quality of life of pediatric low grade glioma treated by postoperative radiotherapy

中华放射肿瘤学杂志 Pub Date : 2020-02-15 DOI:10.3760/CMA.J.ISSN.1004-4221.2020.02.003

P. Xing, Hangzhou Wang, Min Chen, Ye Tian

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Abstract

Objective To analyze the clinical characteristics of children with low grade glioma (LGG) and evaluate their survival status and quality of life in LGG pediatric patients after postoperative radiotherapy. Methods Clinical data of 27 LGG children aged≤14 years admitted to Department of Radiation Oncology of our hospital from January 2011 to December 2017 were retrospectively analyzed. The 5-year overall survival (OS) and progression-free survival (PFS) were estimated with the Kaplan-Meier method.The quality of life was evaluated by body mass index (BMI), WeeFIM and enrollment situation. Results The 5-year OS and PFS of 27 pediatric patients were 92% and 87%. BMI was measured in 25 children who were still alive and the results showed that 1 child was slightly emaciated, 3 were overweight and 21 were normal. The total score of WeeFIM was> 108 in 21 cases and< 90 in 4 cases. In terms of social role-playing assessment, 5 cases delayed enrollment for≥ 2 years, 2 cases had good adaptation except the difficulties due to lameness, 7 of them had poor study performance, but had no communication barrier. Conclusions Children with LGG can obtain relatively excellent OS and PFS after postoperative radiotherapy. Part of the children with long-term survival may experience a declined quality of life, which is mainly manifested with a decline in motor and cognitive functions. Key words: Pediatric low grade glioma/radiotherapy; Survival; Quality of life

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小儿低级别胶质瘤术后放疗的生存分析及生活质量

目的分析儿童低级别胶质瘤（LGG）的临床特点，评价儿童低级别神经胶质瘤患者术后放疗后的生存状况和生活质量。方法回顾性分析我院放射肿瘤科2011年1月至2017年12月收治的27例≤14岁LGG患儿的临床资料。采用Kaplan-Meier方法估计5年总生存期（OS）和无进展生存期（PFS）。通过身体质量指数（BMI）、WeeFIM和入学情况来评估生活质量。结果27例患儿的5年OS和PFS分别为92%和87%。对25名还活着的儿童进行了BMI测量，结果显示，1名儿童轻度消瘦，3名儿童超重，21名儿童正常。WeeFIM总分>108分21例，<90分4例。在社会角色扮演评估方面，5例延迟入学≥2年，2例除跛脚困难外适应良好，其中7例学习成绩较差，但没有沟通障碍。结论LGG患儿术后放疗可获得较好的OS和PFS。部分长期存活的儿童可能会经历生活质量下降，主要表现为运动和认知功能下降。关键词：小儿低级别胶质瘤/放射治疗；存续；生活质量

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来源期刊

中华放射肿瘤学杂志

自引率

0.00%

发文量

6375

期刊介绍： The Chinese Journal of Radiation Oncology is a national academic journal sponsored by the Chinese Medical Association. It was founded in 1992 and the title was written by Chen Minzhang, the former Minister of Health. Its predecessor was the Chinese Journal of Radiation Oncology, which was founded in 1987. The journal is an authoritative journal in the field of radiation oncology in my country. It focuses on clinical tumor radiotherapy, tumor radiation physics, tumor radiation biology, and thermal therapy. Its main readers are middle and senior clinical doctors and scientific researchers. It is now a monthly journal with a large 16-page format and 80 pages of text. For many years, it has adhered to the principle of combining theory with practice and combining improvement with popularization. It now has columns such as monographs, head and neck tumors (monographs), chest tumors (monographs), abdominal tumors (monographs), physics, technology, biology (monographs), reviews, and investigations and research.