Inhalation Toxicity of Coal Fly Ash in Mice Models

Asia Pacific Journal of Medical Toxicology Pub Date : 2020-11-01 DOI:10.22038/APJMT.2020.17364

Dewita Rahmantisa Putri, Latifatu Choirunisa, Isa Ansori

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引用次数: 0

Abstract

Background: Indonesia is one of world’s largest producers of coal. Coal fly ash (CFA), a product of the coal combustion process, consists of various minerals and causes toxic effects by inhalation. This study aimed to analyze the toxic effects of CFA inhalation in mice models by examining oxidative stress and inflammation markers in the blood. Methods: A true experimental with post-test control group design was used in this study. Twenty-four mice were randomly divided into three groups including control (P1), CFA inhalation for 24 hours (P2), and CFA inhalation for 30 days (P3). Mice in the P2 and P3 groups were exposed to CFA measuring 0.075 mm with doses equal to 12.5 mg/m3 for 1 hour/day. Malondialdehyde (MDA) and the percentage of blood eosinophils were examined as parameters of toxic effects. One way analysis of variance (ANOVA) test was used to compare the toxic effects between groups. Results: MDA were significantly increased in between groups (p <0.05). The percentage of blood eosinophils in P1 was significantly differenced to P2 and P3 (p=0.04 and p=0.14, respectively), however there was no different than P2 and P3 (p = 0.891). Conclusions: CFA inhalation induces toxic effects through increased oxidative stress and inflammation in mice models. This may indicates health hazards after CFA inhalation.

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粉煤灰在小鼠模型中的吸入毒性

背景：印度尼西亚是世界上最大的煤炭生产国之一。粉煤灰（CFA）是煤燃烧过程中的产物，由多种矿物质组成，吸入后会产生毒性。本研究旨在通过检测血液中的氧化应激和炎症标志物来分析吸入CFA在小鼠模型中的毒性作用。方法：采用试验后对照组设计的真实实验方法。24只小鼠被随机分为三组，包括对照组（P1）、CFA吸入24小时组（P2）和CFA吸入30天组（P3）。P2和P3组中的小鼠暴露于CFA，CFA测量为0.075mm，剂量等于12.5mg/m3，持续1小时/天。检测丙二醛（MDA）和血液嗜酸性粒细胞百分比作为毒性作用的参数。使用单因素方差分析（ANOVA）检验来比较各组之间的毒性作用。结果：两组间MDA含量均显著升高（p<0.05），P1组与P2组和P3组血嗜酸性粒细胞百分率分别为0.04和0.14，但与P2组、P3组无显著差异（p=0.891）。这可能表明吸入CFA后会对健康造成危害。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asia Pacific Journal of Medical Toxicology

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： Asia Pacific Journal of Medical Toxicology (APJMT) aims to expand the knowledge of medical toxicology and tries to provide reliable information in this field for medical and healthcare professionals. APJMT mainly focuses on research related to medical toxicology issues in the Asia Pacific region and publishes articles on clinical and epidemiological aspects of toxicology, poisonings emergency care, addiction, drug interactions and adverse effects. The journal accepts and welcomes high quality papers in the form of original articles and rarely review articles, case reports and scientific letters relevant to medical practice in toxicology.