The Effect of Zinc Oxide Nanoparticles on Properties and Burn Wound Healing Activity of Thixotropic Xymedone Gels

IF 2.3 Q3 PHARMACOLOGY & PHARMACY

Scientia Pharmaceutica Pub Date : 2022-10-08 DOI:10.3390/scipharm90040061

Ilya Sheferov, A. Balakireva, D. Panteleev, I.V. Spitskaya, S. Orekhov, Oleg Kazantsev, A. Solovyeva, D. Novopoltsev, N. Melnikova

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引用次数: 4

Abstract

Zinc oxide nanoparticles (ZnO NPs) modified by oxopyrymidine alcohol, also known as xymedone (Xym), were obtained and studied using FTIR, UV-vis, and fluorescent spectroscopy, and SEM, BET, powder XRD, and DLS analysis. A formulation of thixotropic hydrophilic gels containing Carbopol-based Xym and ZnO NPs was developed. A vertical Franz cell with a cellulose acetate membrane was used as a model to investigate the passive diffusion of the gel components by AAS. The gel components—Xym and ZnO NPs—were shown to penetrate through acetyl cellulose membrane within 5–7 h depending on an initial amount, and its values were in the range of 56–77%. The penetration of modified ZnO NPs by Xym was more effective in contrast to ZnO NPs without modification. The burn wound healing activity of ZnO NPs–Xym gel was demonstrated on a thermal burn wound model on rats. SOD and GR activity was increased by 30–35% during ZnO NPs–Xym gel treatment, the burn area on 10 postburn day decreased by 10% in contrast to a positive control, Methyluracyl®® ointment.

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氧化锌纳米粒子对触变性Xymedone凝胶性能和烧伤愈合活性的影响

使用FTIR、UV-vis和荧光光谱、SEM、BET、粉末XRD和DLS分析，获得并研究了由氧吡啶醇（也称为xymedone（Xym））改性的氧化锌纳米颗粒（ZnO NPs）。开发了一种含有Carbopol基Xym和ZnO NPs的触变亲水凝胶配方。使用具有醋酸纤维素膜的垂直Franz池作为模型，通过AAS研究凝胶组分的被动扩散。凝胶组分——Xym和ZnO NPs——在5–7小时内穿透乙酰纤维素膜，其值在56–77%之间。与未改性的ZnO NPs相比，Xym对改性ZnO NPs的渗透更有效。在大鼠热烧伤模型上证明了ZnO NPs–Xym凝胶的烧伤愈合活性。在ZnO NPs–Xym凝胶治疗期间，SOD和GR活性增加了30–35%，与阳性对照Methyluracyl®®软膏相比，烧伤后10天的烧伤面积减少了10%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Scientia Pharmaceutica Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

4.60

自引率

4.00%

发文量

审稿时长

10 weeks