Weighted gene co-expression network analysis reveals similarities and differences of molecular features between dilated and ischemic cardiomyopathies

Q1 Engineering
Felix K. Biwott, Ni-Ni Rao, Chang-Long Dong, Guang-Bin Wang
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引用次数: 0

Abstract

Cardiomyopathies represent the most common clinical and genetic heterogeneous group of diseases that affect the heart function. Though progress has been made to elucidate the process, molecular mechanisms of different classes of cardiomyopathies remain elusive. This paper aims to describe the similarities and differences in molecular features of dilated cardiomyopathy (DCM) and ischemic cardiomyopathy (ICM). We firstly detected the co-expressed modules using the weighted gene co-expression network analysis (WGCNA). Significant modules associated with DCM/ICM were identified by the Pearson correlation coefficient (PCC) between the modules and the phenotype of DCM/ICM. The differentially expressed genes in the modules were selected to perform functional enrichment. The potential transcription factors (TFs) prediction was conducted for transcription regulation of hub genes. Apoptosis and cardiac conduction were perturbed in DCM and ICM, respectively. TFs demonstrated that the biomarkers and the transcription regulations in DCM and ICM were different, which helps make more accurate discrimination between them at molecular levels. In conclusion, comprehensive analyses of the molecular features may advance our understanding of DCM and ICM causes and progression. Thus, this understanding may promote the development of innovative diagnoses and treatments.

加权基因共表达网络分析揭示了扩张型和缺血性心肌病分子特征的异同
心肌病是影响心功能的最常见的临床和遗传异质性疾病。虽然在阐明这一过程方面取得了进展,但不同类型心肌病的分子机制仍然难以捉摸。本文旨在描述扩张型心肌病(DCM)和缺血性心肌病(ICM)分子特征的异同。我们首先使用加权基因共表达网络分析(WGCNA)检测共表达模块。通过模块与DCM/ICM表型之间的Pearson相关系数(PCC)鉴定与DCM/ICM相关的显著模块。选择模块中差异表达的基因进行功能富集。对枢纽基因的转录调控进行了潜在转录因子(TFs)预测。在DCM和ICM中,细胞凋亡和心脏传导分别受到干扰。TFs表明DCM和ICM的生物标志物和转录调控不同,这有助于在分子水平上更准确地区分它们。综上所述,全面分析DCM和ICM的分子特征有助于我们了解DCM和ICM的病因和进展。因此,这种认识可能会促进创新诊断和治疗的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Electronic Science and Technology
Journal of Electronic Science and Technology Engineering-Electrical and Electronic Engineering
CiteScore
4.30
自引率
0.00%
发文量
1362
审稿时长
99 days
期刊介绍: JEST (International) covers the state-of-the-art achievements in electronic science and technology, including the most highlight areas: ¨ Communication Technology ¨ Computer Science and Information Technology ¨ Information and Network Security ¨ Bioelectronics and Biomedicine ¨ Neural Networks and Intelligent Systems ¨ Electronic Systems and Array Processing ¨ Optoelectronic and Photonic Technologies ¨ Electronic Materials and Devices ¨ Sensing and Measurement ¨ Signal Processing and Image Processing JEST (International) is dedicated to building an open, high-level academic journal supported by researchers, professionals, and academicians. The Journal has been fully indexed by Ei INSPEC and has published, with great honor, the contributions from more than 20 countries and regions in the world.
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