Prognostic value of trafficking of regulatory T cells to tumors in head and neck cancer patients.

Journal of global oncology Pub Date : 2019-10-07 DOI:10.1200/jgo.2019.5.suppl.104

Hyun Chang, H. Hong, Yongho Kim

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引用次数: 1

Abstract

104 Background: The prognostic value of regulatory T cells (Tregs) in head and neck squamous cell carcinoma (HNSCC) remains unknown. We analyzed the prognostic effect of Tregs in HNSCC with immune activity scores, which reflect the activity status of the seven-step cancer-immunity cycle. Methods: We correlated the 23 immune activity scores and clinicopathologic features of The Cancer Genome Atlas (TCGA) HNSCC using multivariate Cox regression analyses and Kaplan-Meier survival curves. The processed data of immune activity scores were obtained from TIP online tool and the clinicopathologic data were downloaded from TCGA HNSCC database. Results: Immune activity scores of “trafficking of Tregs to tumors” was significantly associated with overall survival (OS) and progression-free survival (PFS). Low activity scores of “trafficking of Tregs to tumors” resulted in shorter OS and PFS. In multivariate analysis, low scores predicted poor OS (adjusted HR = 1.87, 95% CI 1.34-2.60 ; P < 0.001) and were related with unfavorable PFS (adjusted HR = 2.04, 95% CI 1.45-2.86 ; P < 0.001). Conclusions: Immune activity scores of “trafficking of Tregs to tumors” was independent significant prognostic factor in HNSCC. Therefore, assessment of immune activity scores may be useful tools for predicting prognosis in these patients.

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调节性T细胞转运至癌症头颈部肿瘤的预后价值。

104背景：调节性T细胞（Tregs）在头颈部鳞状细胞癌（HNSCC）中的预后价值尚不清楚。我们用免疫活性评分分析了Tregs对HNSCC的预后影响，免疫活性评分反映了七步癌症-免疫循环的活性状态。方法：我们使用多变量Cox回归分析和Kaplan-Meier生存曲线，将癌症基因组图谱（TCGA）HNSCC的23个免疫活性评分与临床病理特征相关联。免疫活性评分的处理数据从TIP在线工具获得，临床病理数据从TCGA HNSCC数据库下载。结果：“Tregs向肿瘤转移”的免疫活性评分与总生存期（OS）和无进展生存期（PFS）显著相关。“Tregs向肿瘤转移”的低活性分数导致OS和PFS缩短。在多变量分析中，低分可预测OS差（校正HR=1.87，95%CI 1.34-2.60；P<0.001），并与不良PFS相关（校正HR=2.04，95%CI 1.45-2.86；P=0.001）。因此，免疫活性评分的评估可能是预测这些患者预后的有用工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of global oncology ONCOLOGY-

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： The Journal of Global Oncology (JGO) is an online only, open access journal focused on cancer care, research and care delivery issues unique to countries and settings with limited healthcare resources. JGO aims to provide a home for high-quality literature that fulfills a growing need for content describing the array of challenges health care professionals in resource-constrained settings face. Article types include original reports, review articles, commentaries, correspondence/replies, special articles and editorials.