L. vannamei shells reduces atherogenic index of plasma: A preclinical study in diabetic rats

Abstract

BACKGROUND: Cardiovascular disease (CVD) appears to be the fundamental cause of morbidity and mortality in type 2 diabetes mellitus (T2DM). Improving the level of lipoprotein ratios using natural ingredients was widely used. OBJECTIVE: This study aimed to examine antioxidant source-Litopenaeus vannamei shell powder (LVSP) to rebalance the lipoprotein ratios in diabetic rats. METHODS: A-14 days prior to streptozotocin (STZ) injection, male Wistar rats (n = 30) were evenly grouped into non-intervention (C–), pre-intervention high-fat diet (C+), pre-intervention high-fat diet with LVSP dose 0.89 g/body weight (BW), pre-intervention high-fat diet with LVSP dose 1.77 g/BW (T2), and pre-intervention high-fat diet with astaxanthin 0.09 mg/BW (T3). RESULTS: A reduction of LDL, total cholesterol (TC), and TC/HDL, LDL/HDL, and LDL/TC ratio was observed (p <  0.001). A negative, strong correlation was found between the change of adiponectin to the change of TC (r=–0.94), LDL (r=–0.92), TC/HDL (r=–0.94), LDL/HDL (r=–0.91), and LDL/TC (r=–0.82). The magnitude of improvement showed a dose-dependent manner, and the high dose delineated a comparable effect to astaxanthin. CONCLUSION: The present study brought a profound finding on the potential of LV to reduce cardiovascular index in T2DM rats.