Epigenetics and Perinatal Depression

Current Psychiatry Reviews Pub Date : 2017-01-17 DOI:10.2174/1573400512666160527170843

Carlos Sabas Cruz Fuentes, M. Flores-Ramos, Philippe Leff, Armando Carvajal-Lohr, G. Martinez-Levy, J. Grajeda, Lorena R-B. Ramirez

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Abstract

Adversity in early life has been associated with consequent altered behaviors or mental disorders during adulthood. Similar observations occur in the intrauterine environment that can disturb the neurodevelopment of the fetus. A particular example of this phenomenon is seen in infants of mothers who experience depression during pregnancy, who seem to be more prone to have emotional disturbances throughout life. The interaction between environmental factors and a genetic predisposition could be an explanation to the association between perinatal depression and psychological symptoms in the offspring. In this regard, it is essential to consider the epigenetic changes that occur in the complex interaction between environment, genetic factors and mood disorders during pre-natal life. It has been observed that epigenetic modifications play a central role as a mediator in the fetal programming of adult health. The aim of our study is to present an updated review of the data regarding epigenetic modifications in specific regions of candidate genes for perinatal depression.

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表观遗传学与围产期抑郁症

早期生活中的逆境与成年后的行为改变或精神障碍有关。类似的观察也出现在宫内环境中，可能会干扰胎儿的神经发育。这种现象的一个特别例子是在怀孕期间经历抑郁症的母亲所生的婴儿身上看到的，这些母亲似乎更容易在一生中出现情绪障碍。环境因素和遗传易感性之间的相互作用可以解释围产期抑郁和后代心理症状之间的联系。在这方面，必须考虑在产前生活中环境、遗传因素和情绪障碍之间复杂的相互作用中发生的表观遗传变化。据观察，表观遗传修饰在成人健康的胎儿编程中起着中介的核心作用。我们研究的目的是对围产期抑郁症候选基因特定区域的表观遗传修饰数据进行最新综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Current Psychiatry Reviews PSYCHIATRY-

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期刊介绍： Current Psychiatry Reviews publishes frontier reviews on all the latest advances on clinical psychiatry and its related areas e.g. pharmacology, epidemiology, clinical care, and therapy. The journal’s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all clinicians, psychiatrists and researchers in psychiatry.