Micronutrients absorbed via the oral mucosa reduce irritability and anger but not stress in university students during COVID-19: A randomized placebo-controlled trial.

IF 2.1 2区心理学 Q3 PSYCHOLOGY, APPLIED

International Journal of Stress Management Pub Date : 2023-04-24 DOI:10.1037/str0000291

Nurina M. Katta, N. Blampied, R. Mulder, J. Rucklidge

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引用次数: 0

Abstract

Research has shown micronutrient capsules can reduce stress in clinical and nonclinical recipients. However, as individuals can struggle with taking capsules, the objective of this double-blind, randomized placebo-controlled trial was to investigate the efficacy and safety of treating stress and well-being using an alternative delivery methodology: a powder that is absorbed via the oral mucosa. Seventy-two mild-severely stressed students, assessed using the Depression Anxiety Stress Scale-21 (DASS-21), were randomized to placebo or micronutrients and took one powder pouch per day for 4 weeks. Seven (10%) dropped out with no group differences. Symptoms of stress, depression, anxiety, irritability, anger, sleep, diet, and side effects were measured with online questionnaires every 2 weeks. There were no group differences on the primary outcome measures of stress (DASS-21;d = 0.15, p = .525) and self-reported improvement (Modified Clinical Global Impressions-Improvement scale), with 17.1% of the micronutrient and 16.2% of the placebo group identifying themselves as "much" to "very much" improved. However, the micronutrient group experienced statistically significantly greater reduction in irritability (d = 0.54, p = .024) and anger (d = 0.62, p = .011) relative to placebo, measured with the Affective Reactivity Scale and the Abbreviated Profile of Mood States, respectively. No group differences were found on remaining measures, with both groups showing significant improvements. There were significantly more headaches and drowsiness reported in the micronutrient group. Belief in treatment assignment was significantly correlated to self-reported improvement (r = -0.247, p = .049). To conclude, the micronutrients were no better than placebo in reducing stress;nonetheless, the significant benefit on irritability requires further research. (PsycInfo Database Record (c) 2023 APA, all rights reserved)

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一项随机安慰剂对照试验:通过口腔黏膜吸收的微量营养素可以减轻大学生在COVID-19期间的烦躁和愤怒，但不能减轻压力。

研究表明，微量营养素胶囊可以减轻临床和非临床受试者的压力。然而，由于个人可能难以服用胶囊，这项双盲、随机安慰剂对照试验的目的是研究使用另一种递送方法治疗压力和健康的疗效和安全性：通过口腔粘膜吸收的粉末。72名轻度-重度压力学生，使用抑郁-焦虑-压力量表-21（DAS-21）进行评估，被随机分为安慰剂或微量营养素组，每天服用一个粉袋，持续4周。7人（10%）退出，无组间差异。每两周通过在线问卷测量一次压力、抑郁、焦虑、易怒、愤怒、睡眠、饮食和副作用的症状。在压力（DAS-21；d=0.15，p=.255）和自我报告的改善（改良临床总体印象改善量表）的主要结果指标上，没有组间差异，17.1%的微量营养素和16.2%的安慰剂组认为自己“非常”到“非常”改善。然而，与安慰剂相比，微量营养素组的易怒（d=0.54，p=.024）和愤怒（d=0.62，p=.011）在统计学上显著减少，分别用情感反应量表和情绪状态简档进行测量。在其余指标上未发现组间差异，两组均显示出显著改善。微量营养素组的头痛和嗜睡明显增多。相信治疗分配与自我报告的改善显著相关（r=-0.247，p=.049）。总之，微量营养素在减轻压力方面并不比安慰剂好；尽管如此，对易怒的显著益处还需要进一步研究。（PsycInfo数据库记录（c）2023 APA，保留所有权利）

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Stress Management PSYCHOLOGY, APPLIED-

CiteScore

5.90

自引率

5.00%

发文量

期刊介绍： The editorial focus of the International Journal of Stress Management® (IJSM) is the assessment, management, and treatment of stress and trauma, whether emotional, cognitive, behavioral, or physiological. Personal, occupational, organizational, and societal issues relevant to stress identification and management are also covered. IJSM publishes articles that advance theory and practice and promotes methodologically sound research in stress identification and management across disciplines that include psychology and other social sciences, psychiatry, medicine, therapy and other healthcare, business and industry, humanities, arts, education, engineering, and others. The journal publishes high-quality, peer-reviewed original research — qualitative and/or quantitative empirical, theoretical, historical, and review articles — as well as brief reports, book reviews, and editorials. Contributions to the IJSM come from an international array of scholars and practitioners who come from varied disciplines around the globe.