PET Imaging for Initial Staging and Therapy Assessment in Multiple Myeloma Patients.

IF 2.781
Clément Bailly, Rodolphe Leforestier, Bastien Jamet, Thomas Carlier, Mickael Bourgeois, François Guérard, Cyrille Touzeau, Philippe Moreau, Michel Chérel, Françoise Kraeber-Bodéré, Caroline Bodet-Milin
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Abstract

Multiple myeloma (MM) is a hematological neoplasm characterized by the clonal proliferation of malignant plasma cells in the bone marrow. MM results in diffuse or focal bone infiltration and extramedullary lesions. Over the past two decades, advances have been made with regard to the diagnosis, staging, treatment, and imaging of MM. Computed tomography (CT) and magnetic resonance imaging (MRI) are currently recommended as the most effective imaging modalities at diagnostic. Yet, recent data from the literature suggest that positron emission tomography combined with computed tomography (PET/CT) using 18F-deoxyglucose (FDG) is a promising technique for initial staging and therapeutic monitoring in this pathology. This paper reviews the recent advances as well as the potential place of a more specific radiopharmaceutical in MM.

PET成像对多发性骨髓瘤患者的初始分期和治疗评估
多发性骨髓瘤(MM)是一种以骨髓中恶性浆细胞克隆性增生为特征的血液肿瘤。MM导致弥漫性或局灶性骨浸润和髓外病变。在过去的二十年中,在MM的诊断、分期、治疗和成像方面取得了进展。计算机断层扫描(CT)和磁共振成像(MRI)目前被推荐为诊断时最有效的成像方式。然而,最近来自文献的数据表明,正电子发射断层扫描结合使用18f -脱氧葡萄糖(FDG)的计算机断层扫描(PET/CT)是一种很有前途的技术,用于该病理的初始分期和治疗监测。本文综述了近年来的研究进展以及一种更特异的放射性药物在MM中的潜在地位。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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