Research progress of hyperleukocytic acute leukemia

国际输血及血液学杂志 Pub Date : 2019-11-20 DOI:10.3760/CMA.J.ISSN.1673-419X.2019.06.013

Yu Hu, Bo Zheng

引用次数: 0

Abstract

Acute hyperleukocytic leukemia (AHL) refers to acute leukemia patients whose peripheral white blood cell count(WBC) is more than 100×109/L. It is called hyperleukocytosis (HL), when peripheral WBC is more than 100×109/L. It is common in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). AHL has a rapid onset, rapid progress, high early mortality and poor prognosis, which is a critical disease in hematology department. Because of its complications such as leukostasis, tumor lysis syndrome (TLS), disseminated intravascular coagulation (DIC), patients′ lives are threatened and need urgent intervention. Therefore, how to reduce the early mortality of patients with AHL is an important research topic. This article reviews the epidemiology, pathophysiology and clinical manifestations of AHL, especially the current treatment options. Key words: Leukocytosis; Leukemia; Tumor lysis syndrome; Acute hyperleukocytic leukemia; Lyperleukocytosis; Early mortality; Epidemiologic studies; Leukostasis

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高白细胞急性白血病的研究进展

急性高白细胞白血病（AHL）是指外周白细胞计数（WBC）超过100×109/L的急性白血病患者。当外周血白细胞超过100×109/L时，称为高白细胞增多症（HL）。它常见于急性髓细胞白血病（AML）和急性淋巴细胞白血病（ALL）。AHL发病快、进展快、早期死亡率高、预后差，是血液科的危重病。由于其并发症如白细胞淤积、肿瘤溶解综合征（TLS）、弥散性血管内凝血（DIC），患者的生命受到威胁，需要紧急干预。因此，如何降低AHL患者的早期死亡率是一个重要的研究课题。本文综述了AHL的流行病学、病理生理学和临床表现，特别是目前的治疗方案。关键词：白细胞增多症；白血病；肿瘤溶解综合征；急性高白细胞白血病；白细胞增多症；早期死亡率；流行病学研究；白血病

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

国际输血及血液学杂志

自引率

0.00%

发文量

10610

期刊介绍： The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.