Mina Asadi-Tarani, Mohsen Saravani, Marzieh Ghasemi, Mahnaz Rezaei, Saeedeh Salimi
{"title":"Maternal and placental <i>ANRIL</i> polymorphisms and preeclampsia susceptibility.","authors":"Mina Asadi-Tarani, Mohsen Saravani, Marzieh Ghasemi, Mahnaz Rezaei, Saeedeh Salimi","doi":"10.2217/pme-2023-0073","DOIUrl":null,"url":null,"abstract":"<p><p><b>Aim:</b> The possible effects of maternal and placental <i>ANRIL</i> polymorphisms on preeclampsia were examined. <b>Methods:</b> The maternal blood of 315 preeclamptic and 317 control women and the placentas of 103 preeclamptic and 133 control women were enrolled in the study. <i>ANRIL</i> polymorphisms were genotyped using a PCR-RFLP method. <b>Results:</b> The maternal <i>ANRIL</i> rs1333048C variant showed a relationship with a lower risk of preeclampsia in codominant and dominant models. The maternal <i>ANRIL</i> rs4977574G variant had a relationship with a lower risk of preeclampsia in codominant and recessive models. There was an association between the placental rs1333048C variant and a lower risk of preeclampsia in codominant and dominant models. <b>Conclusion:</b> Maternal <i>ANRIL</i> rs1333048C and rs4977574G variants and placental rs1333048 variant showed a relationship with a lower risk of preeclampsia.</p>","PeriodicalId":94167,"journal":{"name":"Personalized medicine","volume":"20 5","pages":"445-452"},"PeriodicalIF":0.0000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Personalized medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2217/pme-2023-0073","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/10/18 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Aim: The possible effects of maternal and placental ANRIL polymorphisms on preeclampsia were examined. Methods: The maternal blood of 315 preeclamptic and 317 control women and the placentas of 103 preeclamptic and 133 control women were enrolled in the study. ANRIL polymorphisms were genotyped using a PCR-RFLP method. Results: The maternal ANRIL rs1333048C variant showed a relationship with a lower risk of preeclampsia in codominant and dominant models. The maternal ANRIL rs4977574G variant had a relationship with a lower risk of preeclampsia in codominant and recessive models. There was an association between the placental rs1333048C variant and a lower risk of preeclampsia in codominant and dominant models. Conclusion: Maternal ANRIL rs1333048C and rs4977574G variants and placental rs1333048 variant showed a relationship with a lower risk of preeclampsia.
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