Is high sensitivity troponin, taken regardless of a clinical indication, associated with 1 year mortality in critical care patients?

IF 2.1 Q3 CRITICAL CARE MEDICINE

Journal of the Intensive Care Society Pub Date : 2023-11-01 Epub Date: 2023-03-30 DOI:10.1177/17511437231160078

Jonathan Hinton, Maclyn Augustine, Lavinia Gabara, Mark Mariathas, Rick Allan, Florina Borca, Zoe Nicholas, Neil Gillett, Chun Shing Kwok, Paul Cook, Michael Pw Grocott, Mamas Mamas, Nick Curzen

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引用次数: 0

Abstract

The aim of this study was to assess whether high sensitivity troponin (hs-cTnI) is associated with 1 year mortality in critical care (CC). One year mortality data were obtained from NHS Digital for a consecutive cohort of patients admitted to general CC unit (GCCU) and neuroscience CC unit (NCCU) who had hs-cTnI tests performed throughout their CC admission, regardless of whether the test was clinically indicated. Cox proportional hazards were used to estimate the risk of 1-year mortality. A landmark analysis was undertaken to assess whether any relationship at 1 year was driven by mortality within the first 30 days. A total of 1033 consecutive patients were included. At 1 year 254 (24.6%) patients had died. The admission log(10)hs-cTnI concentration in the entire cohort (HR 1.35 (95% CI 1.05-1.75) p = 0.009 with a bootstrap of 1000 samples) was independently associated with 1 year mortality. On landmark analysis the association with 1 year mortality was driven by 30 day mortality. These results indicate that admission hs-cTnI concentration is independently associated with 1 year mortality in CC and this relationship may be driven by differences in mortality at 30 days.

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无论临床指征如何服用的高敏肌钙蛋白是否与1 重症监护患者的年死亡率？

本研究的目的是评估高灵敏度肌钙蛋白（hs-cTnI）是否与1 重症监护的年死亡率（CC）。从NHS Digital获得了一年的死亡率数据，这些患者在普通CC单元（GCCU）和神经科学CC单元（NCCU）入院期间进行了hs-cTnI测试，无论该测试是否具有临床意义。Cox比例风险用于估计1年死亡率的风险。进行了一项里程碑式的分析，以评估在1 前30年的死亡率天。共纳入1033名连续患者。在1 254年（24.6%）患者死亡。整个队列的入院对数（10）hs-cTnI浓度（HR 1.35（95%CI 1.05-1.75）p = 0.009，具有1000个样本的引导）与1 年死亡率。关于地标分析与1的关联年死亡率由30 日死亡率。这些结果表明，入院hs-cTnI浓度与1 CC的年死亡率和这种关系可能是由30岁时死亡率的差异驱动的天。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Intensive Care Society Nursing-Critical Care Nursing

CiteScore

4.40

自引率

0.00%

发文量

期刊介绍： The Journal of the Intensive Care Society (JICS) is an international, peer-reviewed journal that strives to disseminate clinically and scientifically relevant peer-reviewed research, evaluation, experience and opinion to all staff working in the field of intensive care medicine. Our aim is to inform clinicians on the provision of best practice and provide direction for innovative scientific research in what is one of the broadest and most multi-disciplinary healthcare specialties. While original articles and systematic reviews lie at the heart of the Journal, we also value and recognise the need for opinion articles, case reports and correspondence to guide clinically and scientifically important areas in which conclusive evidence is lacking. The style of the Journal is based on its founding mission statement to ‘instruct, inform and entertain by encompassing the best aspects of both tabloid and broadsheet''.