Chronic periodontitis and risk of cerebro-cardiovascular diseases among older Koreans

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Gerodontology Pub Date : 2023-10-17 DOI:10.1111/ger.12722

Kyeung-Ae Jang, Yu-Rin Kim, Kwangmin Joo, Minkook Son

{"title":"Chronic periodontitis and risk of cerebro-cardiovascular diseases among older Koreans","authors":"Kyeung-Ae Jang, Yu-Rin Kim, Kwangmin Joo, Minkook Son","doi":"10.1111/ger.12722","DOIUrl":null,"url":null,"abstract":"<div>\n \n <section>\n \n <h3> Background and Objective</h3>\n \n <p>There is a relative lack of evidence from observational studies of older populations investigating the association between chronic periodontitis and cerebro-cardiovascular diseases. Accordingly, we investigated the risk of cerebro-cardiovascular diseases according to the severity of chronic periodontitis among older adults.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Data on older adults with chronic periodontitis were extracted from the Korea National Health Insurance Service-Senior Cohort Database using diagnosis codes and dental procedures. Participants were divided into two exposure groups. Among 46 737 participants eligible for inclusion, 21 905 (46.9%) had newly diagnosed mild chronic periodontitis, and 24 832 (53.1%) had newly diagnosed severe chronic periodontitis. To determine the risk of cerebro-cardiovascular diseases, including ischemic stroke, haemorrhagic stroke, and myocardial infarction, multivariable-adjusted Cox proportional hazards modelling was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) in this retrospective follow-up study.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>A total of 3453 (7.4%) outcomes were identified during a mean follow-up of 6.1 years. Kaplan–Meier analysis revealed that disease-free probability was lower in the severe group than in the mild group (log-rank <i>P</i> < .001). In the multivariable-adjusted model, the HR for cerebro-cardiovascular diseases in the severe group (relative to the mild group) was 1.16 (95% CI: 1.09–1.25). In individual outcome analysis, ischemic stroke and myocardial infarction were associated with chronic periodontitis severity, but haemorrhagic stroke was not.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The severity of chronic periodontitis could be associated with the risk of cerebro-cardiovascular diseases in older adults.</p>\n </section>\n </div>","PeriodicalId":12583,"journal":{"name":"Gerodontology","volume":"41 3","pages":"400-408"},"PeriodicalIF":2.0000,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gerodontology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/ger.12722","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

Background and Objective

There is a relative lack of evidence from observational studies of older populations investigating the association between chronic periodontitis and cerebro-cardiovascular diseases. Accordingly, we investigated the risk of cerebro-cardiovascular diseases according to the severity of chronic periodontitis among older adults.

Methods

Data on older adults with chronic periodontitis were extracted from the Korea National Health Insurance Service-Senior Cohort Database using diagnosis codes and dental procedures. Participants were divided into two exposure groups. Among 46 737 participants eligible for inclusion, 21 905 (46.9%) had newly diagnosed mild chronic periodontitis, and 24 832 (53.1%) had newly diagnosed severe chronic periodontitis. To determine the risk of cerebro-cardiovascular diseases, including ischemic stroke, haemorrhagic stroke, and myocardial infarction, multivariable-adjusted Cox proportional hazards modelling was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) in this retrospective follow-up study.

Results

A total of 3453 (7.4%) outcomes were identified during a mean follow-up of 6.1 years. Kaplan–Meier analysis revealed that disease-free probability was lower in the severe group than in the mild group (log-rank P < .001). In the multivariable-adjusted model, the HR for cerebro-cardiovascular diseases in the severe group (relative to the mild group) was 1.16 (95% CI: 1.09–1.25). In individual outcome analysis, ischemic stroke and myocardial infarction were associated with chronic periodontitis severity, but haemorrhagic stroke was not.

Conclusion

The severity of chronic periodontitis could be associated with the risk of cerebro-cardiovascular diseases in older adults.

查看原文本刊更多论文

韩国老年人的慢性牙周炎和患脑心血管疾病的风险。

背景和目的：研究慢性牙周炎与脑心血管疾病之间关系的老年人群观察性研究相对缺乏证据。因此，我们根据老年人慢性牙周炎的严重程度调查了患脑心血管疾病的风险。方法：使用诊断代码和牙科程序从韩国国家健康保险服务高级队列数据库中提取患有慢性牙周炎的老年人的数据。参与者被分为两组。46人中有资格入选的737名参与者，21人 905人（46.9%）新诊断为轻度慢性牙周炎，24人 832例（53.1%）新诊断为重度慢性牙周炎。为了确定脑心血管疾病的风险，包括缺血性中风、出血性中风和心肌梗死，在这项回顾性随访研究中，使用多变量调整的Cox比例风险模型来计算风险比（HR）和95%置信区间（CI）。结果：在6.1的平均随访中，共发现3453例（7.4%）结果年。Kaplan-Meier分析显示，重症组的无病概率低于轻症组（log秩P 结论：慢性牙周炎的严重程度可能与老年人患脑心血管疾病的风险有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Gerodontology 医学-老年医学

CiteScore

4.10

自引率

10.00%

发文量

审稿时长

3-6 weeks

期刊介绍： The ultimate aim of Gerodontology is to improve the quality of life and oral health of older people. The boundaries of most conventional dental specialties must be repeatedly crossed to provide optimal dental care for older people. In addition, management of other health problems impacts on dental care and clinicians need knowledge in these numerous overlapping areas. Bringing together these diverse topics within one journal serves clinicians who are seeking to read and to publish papers across a broad spectrum of specialties. This journal provides the juxtaposition of papers from traditional specialties but which share this patient-centred interest, providing a synergy that serves progress in the subject of gerodontology.