Among females older than 50 years, saliva secretion is significantly lower in non-erosive reflux disease patients than in healthy controls.

IF 2.2 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

Esophagus Pub Date : 2024-01-01 Epub Date: 2023-10-16 DOI:10.1007/s10388-023-01025-9

Yoshimasa Hoshikawa, Eri Momma, Mai Koeda, Tomohide Tanabe, Shintaro Hoshino, Noriyuki Kawami, Katsuhiko Iwakiri

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引用次数: 0

Abstract

Background: Saliva secretion is significantly lower in patients with non-erosive reflux disease (NERD) than in healthy controls (HC). A previous study on HC showed that saliva secretion was lower in females than in males. Saliva secretion may be lower in female patients with NERD than in male patients. Therefore, the present study investigated sex differences in saliva secretion in patients with NERD.

Methods: Subjects older than 50 years were included in the present study and consisted of 20 male patients with NERD, 19 male HC, 25 female patients with NERD, and 23 female HC. Saliva secretion was assessed as follows: each patient chewed sugar-free gum for 3 min prior to endoscopy, and the amount and pH of saliva before and after acid loading as an index of the acid-buffering capacity were measured.

Results: In males, no significant differences were observed in the amount of stimulated saliva secretion or salivary pH between NERD patients and HC. However, the acid-buffering capacity (NERD: 6.1 [5.9-6.5], HC: 6.4 [6.2-6.6]) was significantly lower in NERD patients than in HC. In females, the amount of stimulated saliva secretion (NERD: 2.6 [2.0-4.1], HC: 5.8 [3.7-7.5]), salivary pH (NERD: 7.0 [6.8-7.2], HC: 7.2 [7.0-7.2]), and the acid-buffering capacity (NERD: 5.8 [5.4-6.2], HC: 6.2 [6.0-6.5]) were significantly lower in NERD patients than in HC.

Conclusion: Among females older than 50 years, saliva secretion was significantly lower in NERD patients than in HC. This reduction in saliva secretion may contribute to the pathophysiology of NERD in females.

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在50岁以上的女性中，非糜烂性反流病患者的唾液分泌明显低于健康对照组。

背景：非糜烂性反流病（NERD）患者的唾液分泌明显低于健康对照组（HC）。先前一项关于HC的研究表明，女性的唾液分泌量低于男性。女性NERD患者的唾液分泌可能低于男性患者。因此，本研究调查了NERD患者唾液分泌的性别差异。方法：50岁以上的受试者包括20名男性NERD患者、19名男性HC患者、25名女性NERD患者和23名女性HC患者。唾液分泌评估如下：每个患者在内窥镜检查前咀嚼无糖口香糖3分钟，并测量酸负荷前后唾液的量和pH值，作为酸缓冲能力的指标。结果：在男性中，NERD患者和HC在刺激唾液分泌量或唾液pH值方面没有观察到显著差异。然而，NERD患者的酸缓冲能力（NERD:6.1[5.9-6.5]，HC:6.4[6.2-6.6]）显著低于HC。女性受刺激唾液分泌量（NERD:2.6[2.0-4.1]，HC:5.8[3.7-7.5]）、唾液pH值（NERD:7.0[6.8-7.2]，HC:7.2[7.0-7.2]）和酸缓冲能力（NERD:5.8[5.4-6.2]，HC:6.2[6.0-6.5]）明显低于HC。结论：在50岁以上的女性中，NERD患者的唾液分泌明显低于HC患者。唾液分泌的减少可能有助于女性NERD的病理生理学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Esophagus GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

4.90

自引率

8.30%

发文量

审稿时长

>12 weeks

期刊介绍： Esophagus, the official journal of the Japan Esophageal Society, introduces practitioners and researchers to significant studies in the fields of benign and malignant diseases of the esophagus. The journal welcomes original articles, review articles, and short articles including technical notes ( How I do it ), which will be peer-reviewed by the editorial board. Letters to the editor are also welcome. Special articles on esophageal diseases will be provided by the editorial board, and proceedings of symposia and workshops will be included in special issues for the Annual Congress of the Society.