{"title":"Gold nanoparticle-based drug nanocarriers as a targeted drug delivery system platform for cancer therapeutics: a systematic review","authors":"A’liyatur Rosyidah, Supavadee Kerdtoob, Wecka Imam Yudhistyra, Asef Wildan Munfadlila","doi":"10.1007/s13404-023-00331-5","DOIUrl":null,"url":null,"abstract":"<div><p>Cancer was the world’s second major cause of death. Several treatments were available, including chemotherapy, radiotherapy, immunotherapy, and surgery. However, they are restricted due to their risk to normal cells, their ability to destroy the immune system, and conferring increased risk of secondary cancer development. Nanotechnology was extensively researched and used in cancer treatment because nanoparticles could play an essential role in drug delivery. Furthermore, nanoparticle drug delivery systems have been shown to help overcome cancer-related drug resistance. Gold nanoparticles have unique physical, chemical, and biological properties, making them suitable candidates for non-toxic drug carriers. Because of their nanorange size, surface modifications of gold nanoparticles could improve their stability, minimize nanoparticle aggregation, and enhance attachment to anti-cancer agents and target cells, further increasing their ability to penetrate cell membranes and reduce toxicity. This review aims to discuss the current research in targeting drug delivery for anti-cancer agents using gold nanoparticles. By conducting a literature search through the PubMed and Scopus database up to April 2022 using the term gold nanoparticles, targeted drug delivery, chemotherapy, gene therapy, and cancer, this review summarized report on the implementation of gold nanoparticles for targeted drug-delivery systems for cancer therapeutics. The targeting ligands included folic acid, aptamers, hyaluronic acid, glutathione, peptides, and antibodies. According to the findings of studies, implementing gold nanoparticles as nanocarriers significantly improves drug delivery of anti-cancer agents to cancer cells without affecting other untargeted cells. Enhanced cell uptake, increase in drug toxicity, inhibition of tumor growth, and selective drug target are also reported to be the advantages of gold nanoparticle-based targeted drug delivery carriers.</p></div>","PeriodicalId":581,"journal":{"name":"Gold Bulletin","volume":"56 3","pages":"121 - 134"},"PeriodicalIF":2.1000,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13404-023-00331-5.pdf","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gold Bulletin","FirstCategoryId":"5","ListUrlMain":"https://link.springer.com/article/10.1007/s13404-023-00331-5","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
引用次数: 1
Abstract
Cancer was the world’s second major cause of death. Several treatments were available, including chemotherapy, radiotherapy, immunotherapy, and surgery. However, they are restricted due to their risk to normal cells, their ability to destroy the immune system, and conferring increased risk of secondary cancer development. Nanotechnology was extensively researched and used in cancer treatment because nanoparticles could play an essential role in drug delivery. Furthermore, nanoparticle drug delivery systems have been shown to help overcome cancer-related drug resistance. Gold nanoparticles have unique physical, chemical, and biological properties, making them suitable candidates for non-toxic drug carriers. Because of their nanorange size, surface modifications of gold nanoparticles could improve their stability, minimize nanoparticle aggregation, and enhance attachment to anti-cancer agents and target cells, further increasing their ability to penetrate cell membranes and reduce toxicity. This review aims to discuss the current research in targeting drug delivery for anti-cancer agents using gold nanoparticles. By conducting a literature search through the PubMed and Scopus database up to April 2022 using the term gold nanoparticles, targeted drug delivery, chemotherapy, gene therapy, and cancer, this review summarized report on the implementation of gold nanoparticles for targeted drug-delivery systems for cancer therapeutics. The targeting ligands included folic acid, aptamers, hyaluronic acid, glutathione, peptides, and antibodies. According to the findings of studies, implementing gold nanoparticles as nanocarriers significantly improves drug delivery of anti-cancer agents to cancer cells without affecting other untargeted cells. Enhanced cell uptake, increase in drug toxicity, inhibition of tumor growth, and selective drug target are also reported to be the advantages of gold nanoparticle-based targeted drug delivery carriers.
期刊介绍：
Gold Bulletin is the premier international peer reviewed journal on the latest science, technology and applications of gold. It includes papers on the latest research advances, state-of-the-art reviews, conference reports, book reviews and highlights of patents and scientific literature. Gold Bulletin does not publish manuscripts covering the snthesis of Gold nanoparticles in the presence of plant extracts or other nature-derived extracts. Gold Bulletin has been published over 40 years as a multidisciplinary journal read by chemists, physicists, engineers, metallurgists, materials scientists, biotechnologists, surface scientists, and nanotechnologists amongst others, both within industry and academia. Gold Bulletin is published in Association with the World Gold Council.
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