Positive effects of systemic sodium benzoate and olanzapine treatment on activities of daily life, spatial learning and working memory in ketamine-induced rat model of schizophrenia.

International journal of physiology, pathophysiology and pharmacology Pub Date : 2019-04-15 eCollection Date: 2019-01-01
Ghada S Mahmoud, Sally A Sayed, Shehabeldin N Abdelmawla, Mohamed A Amer
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Abstract

Background: Sodium Benzoate (SB) significantly improved positive, negative, and cognitive symptoms as add on treatment in schizophrenia. Olanzapine (Ola), the most effective atypical antipsychotic drug, has been linked to hepatic steatosis, acute kidney injury, reproductive side effects and poor effect on negative symptoms in some patients.

Goals: is to compare the efficacy and check the safety of long-term monotherapy with SB 0.01 mg/Kg versus Ola on male cognitive, memory, hepatic, renal and testicular functions in rat model of schizophrenia.

Methods: 48 young adult male rats were divided into 6 groups; C: control; O: received Ola; SB: received SB; K: received single IP ketamine (Ket) injection; K+O: received Ola and Ket and K+SB: received SB and Ket. Ola and SB given orally for 3 or 10 weeks for behavioral or serological studies respectively. We measured activities of daily life (ADL), spatial learning and memory in radial arm water maze (RAWM), serum parameters of hepatic, renal and testicular functions.

Results: Both Ola and SB significantly improved hoarding and burrowing, caused significant decrease in time to reach target (TRT), working memory errors (WME) in K+O and K+SB groups compared to K group. Ola caused significant increase in ALT, AST and creatinine and decrease in serum LH, testosterone compared to controls. SB caused significant rise in serum LH, ALT, AST and decrease in protein and albumin compared to both C and O groups.

Conclusion: Both Ola and SB improved ADL, cognitive and memory functions. Although SB saved testicular and renal functions, it worsened liver function compared to Ola.

Abstract Image

Abstract Image

全身苯甲酸钠和奥氮平治疗对氯胺酮诱导的精神分裂症大鼠日常生活活动、空间学习和工作记忆的积极影响。
背景:苯甲酸钠(SB)作为精神分裂症的辅助治疗,显著改善了阳性、阴性和认知症状。奥氮平(Ola)是最有效的非典型抗精神病药物,与一些患者的肝脂肪变性、急性肾损伤、生殖副作用和对阴性症状的不良影响有关。目的:比较SB 0.01 mg/Kg与Ola对精神分裂症大鼠模型雄性认知、记忆、肝、肾和睾丸功能的长期单一疗法的疗效和安全性。方法:将48只青年成年雄性大鼠分为6组;C: 控制;O: 收到Ola;SB:收到SB;K: 接受单次IP氯胺酮(Ket)注射;K+O:接受Ola和Ket,K+SB:接受SB和Ket。Ola和SB分别口服3周或10周进行行为学或血清学研究。我们测量了日常生活能力(ADL)、桡臂水迷宫(RAWM)中的空间学习和记忆,以及肝、肾和睾丸功能的血清参数。结果:与K组相比,Ola和SB显著改善了K+O和K+SB组的囤积和挖洞,导致达到目标的时间(TRT)和工作记忆错误(WME)显著减少。与对照组相比,Ola导致ALT、AST和肌酐显著升高,血清LH和睾酮降低。与C组和O组相比,SB导致血清LH、ALT、AST显著升高,蛋白质和白蛋白降低。结论:Ola和SB均能改善ADL、认知和记忆功能。尽管SB挽救了睾丸和肾功能,但与Ola相比,它使肝功能恶化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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