The relationship between skeletal muscle mass and exercise capacity in patients undergoing hemodialysis: An exploratory secondary-analysis

IF 1.2 4区 医学 Q3 UROLOGY & NEPHROLOGY
Xuanrui Zhang, Yan Zhuang, Wen Qin, Lun Yang, Yan Song
{"title":"The relationship between skeletal muscle mass and exercise capacity in patients undergoing hemodialysis: An exploratory secondary-analysis","authors":"Xuanrui Zhang,&nbsp;Yan Zhuang,&nbsp;Wen Qin,&nbsp;Lun Yang,&nbsp;Yan Song","doi":"10.1111/hdi.13115","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Protein-energy wasting is commonly observed in patients undergoing hemodialysis, leading to reduced muscle mass and, in severe cases, sarcopenia, which significantly impacts the patients' quality of life and clinical outcomes. Exercise interventions are frequently employed to address muscle loss in these patients. However, the relationship between exercise capacity and skeletal muscle mass in this context remains uncertain. In this study, researchers conducted a series of body composition analysis and exercise capacity test to explore the relationship between exercise capacity and skeletal muscle mass.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>This study recruited 32 patients undergoing hemodialysis and analyzed their demographic and clinical parameters. To assess aerobic exercise capacity, the incremental shuttle walking test (ISWT) was conducted, while the handgrip strength test was used to evaluate muscle strength. The patients' body compositions were assessed using the Fresenius Body Composition Monitor, and the appendicular skeletal muscle was scanned using a GE Healthcare Lunar iDXA scanner. Three sequential linear models were employed to model the relationship between ISWT and skeletal muscle mass. Model 1 regressed ISWT against gender and age; Model 2 added handgrip strength, fat tissue index, and Davies comorbidity scores as additional predictors; and Model 3 further included the appendicular skeletal muscle index (appendicular skeletal muscle/height).</p>\n </section>\n \n <section>\n \n <h3> Findings</h3>\n \n <p>After controlling for age and gender (Model 1: <i>R</i><sup>2</sup> = 0.373), and subsequently including handgrip strength, fat tissue index, and Davies comorbidity score effects (Model 2: <i>R</i><sup>2</sup> = 0.581), the impact of appendicular skeletal muscle on ISWT was found to be non-significant (Model 3: <i>R</i><sup>2</sup> = 0.600).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>There was no significant correlation observed between exercise capacity and skeletal muscle mass in patients undergoing hemodialysis, indicating the factors influencing exercise capacity in this patient population are complex and that increasing skeletal muscle mass may not necessarily involve solely addressing the improvement of exercise capacity.</p>\n </section>\n </div>","PeriodicalId":12815,"journal":{"name":"Hemodialysis International","volume":null,"pages":null},"PeriodicalIF":1.2000,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hemodialysis International","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/hdi.13115","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background

Protein-energy wasting is commonly observed in patients undergoing hemodialysis, leading to reduced muscle mass and, in severe cases, sarcopenia, which significantly impacts the patients' quality of life and clinical outcomes. Exercise interventions are frequently employed to address muscle loss in these patients. However, the relationship between exercise capacity and skeletal muscle mass in this context remains uncertain. In this study, researchers conducted a series of body composition analysis and exercise capacity test to explore the relationship between exercise capacity and skeletal muscle mass.

Methods

This study recruited 32 patients undergoing hemodialysis and analyzed their demographic and clinical parameters. To assess aerobic exercise capacity, the incremental shuttle walking test (ISWT) was conducted, while the handgrip strength test was used to evaluate muscle strength. The patients' body compositions were assessed using the Fresenius Body Composition Monitor, and the appendicular skeletal muscle was scanned using a GE Healthcare Lunar iDXA scanner. Three sequential linear models were employed to model the relationship between ISWT and skeletal muscle mass. Model 1 regressed ISWT against gender and age; Model 2 added handgrip strength, fat tissue index, and Davies comorbidity scores as additional predictors; and Model 3 further included the appendicular skeletal muscle index (appendicular skeletal muscle/height).

Findings

After controlling for age and gender (Model 1: R2 = 0.373), and subsequently including handgrip strength, fat tissue index, and Davies comorbidity score effects (Model 2: R2 = 0.581), the impact of appendicular skeletal muscle on ISWT was found to be non-significant (Model 3: R2 = 0.600).

Conclusion

There was no significant correlation observed between exercise capacity and skeletal muscle mass in patients undergoing hemodialysis, indicating the factors influencing exercise capacity in this patient population are complex and that increasing skeletal muscle mass may not necessarily involve solely addressing the improvement of exercise capacity.

血液透析患者骨骼肌质量与运动能力的关系:探索性二次分析。
背景:在接受血液透析的患者中,通常会观察到蛋白质能量消耗,导致肌肉质量减少,在严重情况下,还会出现少肌症,这会严重影响患者的生活质量和临床结果。经常采用运动干预来解决这些患者的肌肉损失问题。然而,在这种情况下,运动能力和骨骼肌质量之间的关系仍然不确定。在这项研究中,研究人员进行了一系列的身体成分分析和运动能力测试,以探索运动能力与骨骼肌质量之间的关系。方法:本研究招募了32名接受血液透析的患者,并分析了他们的人口统计学和临床参数。为了评估有氧运动能力,进行了增量穿梭步行测试(ISWT),而握力测试用于评估肌肉力量。使用费森尤斯身体成分监测仪评估患者的身体成分,并使用GE Healthcare Lunar iDXA扫描仪扫描阑尾骨骼肌。采用三个连续线性模型对ISWT与骨骼肌质量之间的关系进行建模。模型1根据性别和年龄对ISWT进行回归;模型2增加了握力、脂肪组织指数和Davies共病评分作为额外的预测因素;模型3进一步包括阑尾骨骼肌指数(阑尾骨骼肌/身高)。研究结果:在控制了年龄和性别后(模型1:R2 = 0.373),随后包括握力、脂肪组织指数和Davies共病评分效应(模型2:R2 = 0.581),发现阑尾骨骼肌对ISWT的影响不显著(模型3:R2 = 0.600)。结论:在接受血液透析的患者中,运动能力和骨骼肌质量之间没有观察到显著的相关性,这表明影响该患者群体运动能力的因素是复杂的,增加骨骼肌质量可能不一定只涉及运动能力的提高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Hemodialysis International
Hemodialysis International UROLOGY & NEPHROLOGY-
CiteScore
2.50
自引率
0.00%
发文量
58
审稿时长
6-12 weeks
期刊介绍: Hemodialysis International was originally an annual publication containing the Proceedings of the International Symposium on Hemodialysis held in conjunction with the Annual Dialysis Conference. Since 2003, Hemodialysis International is published quarterly and contains original papers on clinical and experimental topics related to dialysis in addition to the Annual Dialysis Conference supplement. This journal is a must-have for nephrologists, nurses, and technicians worldwide. Quarterly issues of Hemodialysis International are included with your membership to the International Society for Hemodialysis. The journal contains original articles, review articles, and commentary to keep readers completely updated in the field of hemodialysis. Edited by international and multidisciplinary experts, Hemodialysis International disseminates critical information in the field.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信