Skeletal Growth Arrest Lines in Fetal Remains: Histopathology and Correlative Placental Pathology.

IF 1.3 4区医学 Q3 PATHOLOGY

Pediatric and Developmental Pathology Pub Date : 2024-01-01 Epub Date: 2023-10-11 DOI:10.1177/10935266231195750

Tsz Wing Chu, Patrick Shannon, Tony Parks

{"title":"Skeletal Growth Arrest Lines in Fetal Remains: Histopathology and Correlative Placental Pathology.","authors":"Tsz Wing Chu, Patrick Shannon, Tony Parks","doi":"10.1177/10935266231195750","DOIUrl":null,"url":null,"abstract":"Introduction: Skeletal growth arrest lines (GAL) are transverse lines of metaphyseal radiodensity accompanying episodic severe physiological stress. They are poorly described in fetal remains.Materials and methods: We searched our autopsy practice for instances of fetal GAL in post mortem radiology, and correlated them with long bone histology and placental pathology. We describe the appearance, distribution, and pathology of GAL in a cohort of fetal autopsies, and compare the placental pathology accompanying GAL to the placental pathology of asymmetrical growth restriction (AGR) in the same time period.Results: In 2108 consecutive fetal post mortems, we found 20 cases with GAL. About 16 were in singletons with AGR. In these 16, the distribution of placental pathologies was similar to a contemporaneous cohort of 113 cases with AGR. Of the remaining 4, two twins out of 9 sets of monochorionic twins with AGR demonstrated GAL. One case of GAL had symmetrical growth restriction with cytomegalovirus infection, and one case had no AGR and an old, unexplained retroplacental hemorrhage. On histology, GAL are characterized by a region of mineralized chondroid, which is variably incorporated into irregular trabecular bone.Discussion: GALs accompany a variety of placental pathologies and twin-twin transfusion, suggesting episodic disease progression.","PeriodicalId":54634,"journal":{"name":"Pediatric and Developmental Pathology","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric and Developmental Pathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/10935266231195750","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/10/11 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"PATHOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: Skeletal growth arrest lines (GAL) are transverse lines of metaphyseal radiodensity accompanying episodic severe physiological stress. They are poorly described in fetal remains.

Materials and methods: We searched our autopsy practice for instances of fetal GAL in post mortem radiology, and correlated them with long bone histology and placental pathology. We describe the appearance, distribution, and pathology of GAL in a cohort of fetal autopsies, and compare the placental pathology accompanying GAL to the placental pathology of asymmetrical growth restriction (AGR) in the same time period.

Results: In 2108 consecutive fetal post mortems, we found 20 cases with GAL. About 16 were in singletons with AGR. In these 16, the distribution of placental pathologies was similar to a contemporaneous cohort of 113 cases with AGR. Of the remaining 4, two twins out of 9 sets of monochorionic twins with AGR demonstrated GAL. One case of GAL had symmetrical growth restriction with cytomegalovirus infection, and one case had no AGR and an old, unexplained retroplacental hemorrhage. On histology, GAL are characterized by a region of mineralized chondroid, which is variably incorporated into irregular trabecular bone.

Discussion: GALs accompany a variety of placental pathologies and twin-twin transfusion, suggesting episodic disease progression.

查看原文本刊更多论文

胎儿遗骸中的骨骼生长抑制系：组织病理学和相关胎盘病理学。

简介：骨骼生长停止线（GAL）是伴随发作性严重生理应激的干骺端放射密度的横向线。胎儿遗骸中对它们的描述很差。材料和方法：我们在尸检实践中搜索尸检放射学中胎儿GAL的实例，并将其与长骨组织学和胎盘病理学相关联。我们在一组胎儿尸检中描述了GAL的外观、分布和病理，并将同一时间段内伴随GAL的胎盘病理与不对称生长限制（AGR）的胎盘病理进行了比较。结果：在连续2108例胎儿尸检中，我们发现了20例GAL，其中约16例为AGR单胎。在这16例中，胎盘病理的分布与同期113例AGR病例的队列相似。在剩下的4例中，9对患有AGR的单核细胞双胞胎中有两对出现了GAL。一例GAL因巨细胞病毒感染而出现对称性生长受限，一例没有AGR，并出现了一例陈旧的、无法解释的胎盘后出血。在组织学上，GAL的特征是矿化软骨样区域，其可变地结合到不规则的小梁骨中。讨论：GAL伴随各种胎盘病变和双胎输血，提示疾病的偶发性进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Pediatric and Developmental Pathology 医学-病理学

CiteScore

3.70

自引率

5.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal covers the spectrum of disorders of early development (including embryology, placentology, and teratology), gestational and perinatal diseases, and all diseases of childhood. Studies may be in any field of experimental, anatomic, or clinical pathology, including molecular pathology. Case reports are published only if they provide new insights into disease mechanisms or new information.