Genome Instability and DNA Repair in Somatic and Reproductive Aging.

IF 28.4 1区医学 Q1 PATHOLOGY

Annual Review of Pathology-Mechanisms of Disease Pub Date : 2024-01-24 Epub Date: 2023-10-13 DOI:10.1146/annurev-pathmechdis-051122-093128

Stephanie Panier, Siyao Wang, Björn Schumacher

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引用次数: 0

Abstract

Genetic material is constantly subjected to genotoxic insults and is critically dependent on DNA repair. Genome maintenance mechanisms differ in somatic and germ cells as the soma only requires maintenance during an individual's lifespan, while the germline indefinitely perpetuates its genetic information. DNA lesions are recognized and repaired by mechanistically highly diverse repair machineries. The DNA damage response impinges on a vast array of homeostatic processes and can ultimately result in cell fate changes such as apoptosis or cellular senescence. DNA damage causally contributes to the aging process and aging-associated diseases, most prominently cancer. By causing mutations, DNA damage in germ cells can lead to genetic diseases and impact the evolutionary trajectory of a species. The mechanisms ensuring tight control of germline DNA repair could be highly instructive in defining strategies for improved somatic DNA repair. They may provide future interventions to maintain health and prevent disease during aging.

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体细胞和生殖衰老中的基因组不稳定性和DNA修复。

遗传物质不断受到基因毒性的伤害，并且严重依赖于DNA修复。体细胞和生殖细胞的基因组维持机制不同，因为体细胞只需要在个体的一生中进行维持，而种系则无限期地延续其遗传信息。DNA损伤是通过机械高度多样化的修复机制识别和修复的。DNA损伤反应影响了大量的稳态过程，并最终导致细胞命运的变化，如细胞凋亡或细胞衰老。DNA损伤导致衰老过程和衰老相关疾病，最突出的是癌症。通过引起突变，生殖细胞中的DNA损伤可以导致遗传疾病，并影响物种的进化轨迹。确保严格控制种系DNA修复的机制可能对确定改进体细胞DNA修复的策略具有高度指导意义。它们可能提供未来的干预措施，以在衰老期间保持健康和预防疾病。《病理学年度评论：疾病机制》第19卷预计最终在线出版日期为2024年1月。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual Review of Pathology-Mechanisms of Disease 医学-病理学

CiteScore

62.60

自引率

0.00%

发文量

期刊介绍： The Annual Review of Pathology: Mechanisms of Disease is a scholarly journal that has been published since 2006. Its primary focus is to provide a comprehensive overview of recent advancements in our knowledge of the causes and development of significant human diseases. The journal places particular emphasis on exploring the current and evolving concepts of disease pathogenesis, as well as the molecular genetic and morphological changes associated with various diseases. Additionally, the journal addresses the clinical significance of these findings. In order to increase accessibility and promote the broad dissemination of research, the current volume of the journal has transitioned from a gated subscription model to an open access format. This change has been made possible through the Annual Reviews' Subscribe to Open program, which allows all articles published in this volume to be freely accessible to readers. As part of this transition, all articles in the journal are published under a Creative Commons Attribution (CC BY) license, which encourages open sharing and use of the research.