Internal comorbidities and complications of multiple sclerosis therapy - don't be caught off guard!

Q4 Medicine
Dominika Šťastná, Jana Seňavová, Michaela Andělová, Ingrid Menkyová, Otakar Pšenička, Dana Horáková
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引用次数: 0

Abstract

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system, mainly affecting young adults. Factors positively influencing its course include early antiinflammatory treatment and the influencing of other comorbidities. The most common comorbidities occurring in MS patients with a higher frequency than in the general population are neurological, psychiatric, cardiovascular, metabolic and autoimmune. Just as comorbidity compensation affects the course of MS, in some cases, MS decompensation is associated with a worse course of associated diseases. Due to common risk factors and partially shared immunopathogenesis, treatment covering multiple conditions can be used, especially for some autoimmune diseases. On the other hand, some drugs may potentiate the development of other autoimmunity or disorder. A special topic is the side effects and complications of treatment (especially infections and malignancies) of disease-modifying therapies used in patients with MS. However, the potential treatment discontinuation carries significant risks and should always be discussed with the MS specialist. Therefore, close interdisciplinary collaboration is crucial.

多发性硬化症治疗的内部合并症和并发症——不要措手不及!
多发性硬化症(MS)是一种中枢神经系统的慢性自身免疫性疾病,主要影响年轻人。积极影响其病程的因素包括早期抗炎治疗和其他合并症的影响。多发性硬化症患者最常见的合并症是神经、精神、心血管、代谢和自身免疫,其发生频率高于普通人群。正如共病补偿影响多发性硬化症的病程一样,在某些情况下,多发性痴呆症失代偿与相关疾病的病程恶化有关。由于常见的风险因素和部分共同的免疫发病机制,可以使用涵盖多种疾病的治疗方法,尤其是对一些自身免疫性疾病。另一方面,一些药物可能会增强其他自身免疫或疾病的发展。一个特别的话题是MS患者使用的疾病改良疗法的副作用和治疗并发症(尤其是感染和恶性肿瘤)。然而,潜在的治疗中断具有重大风险,应始终与MS专家讨论。因此,密切的跨学科合作至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Vnitrni lekarstvi
Vnitrni lekarstvi Medicine-Internal Medicine
CiteScore
0.50
自引率
0.00%
发文量
104
期刊介绍: Vnitřní lékařství je tiskovým orgánem České internistické společnosti České lékařské společnosti Jana Evangelisty Purkyně a Slovenskej internistickej spoločnosti Slovenskej lekárskej spoločnosti. Je vydáván nepřetržitě od roku 1955. Časopis vychází jako měsíčník, tedy 12krát do roka a podle potřeby jsou v běžném ročníku vydávána jeho suplementa, která jsou obsahově zaměřena k určitému tématu. Tematicky je časopis zaměřen široce na oblast interní medicíny se zvláštní pozorností ke kardiologii, diabetologii a poruchám metabolizmu.
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