Directed evolution as a tool for the selection of oncolytic RNA viruses with desired phenotypes.

IF 6.7
Oncolytic Virotherapy Pub Date : 2019-07-12 eCollection Date: 2019-01-01 DOI:10.2147/OV.S176523
Sergei S Zainutdinov, Galina V Kochneva, Sergei V Netesov, Peter M Chumakov, Olga V Matveeva
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引用次数: 0

Abstract

Viruses have some characteristics in common with cell-based life. They can evolve and adapt to environmental conditions. Directed evolution can be used by researchers to produce viral strains with desirable phenotypes. Through bioselection, improved strains of oncolytic viruses can be obtained that have better safety profiles, increased specificity for malignant cells, and more efficient spread among tumor cells. It is also possible to select strains capable of killing a broader spectrum of cancer cell variants, so as to achieve a higher frequency of therapeutic responses. This review describes and analyses virus adaptation studies performed with members of four RNA virus families that are used for viral oncolysis: reoviruses, paramyxoviruses, enteroviruses, and rhabdoviruses.

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定向进化作为选择具有所需表型的溶瘤RNA病毒的工具。
病毒与以细胞为基础的生命有一些共同特征。它们可以进化并适应环境条件。研究人员可以利用定向进化产生具有理想表型的病毒株。通过生物选择,可以获得具有更好的安全性、对恶性细胞的特异性增加以及在肿瘤细胞中更有效传播的改进的溶瘤病毒株。还可以选择能够杀死更广泛的癌症细胞变体的菌株,以实现更高频率的治疗反应。这篇综述描述并分析了对四个用于病毒溶瘤的RNA病毒家族成员进行的病毒适应研究:呼肠孤病毒、副粘病毒、肠道病毒和弹状病毒。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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