Contrast-Enhanced Ultrasound Liver Imaging Reporting and Data System in Hepatocellular Carcinoma ≤5 cm: Biological Characteristics and Patient Outcomes.

IF 11.6 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Liver Cancer Pub Date : 2023-01-24 eCollection Date: 2023-09-01 DOI:10.1159/000527498

Wen-Jia Cai, Minghua Ying, Rong-Qin Zheng, Jintang Liao, Baoming Luo, Lina Tang, Wen Cheng, Hong Yang, An Wei, Yilin Yang, Hui Wang, Yan-Chun Luo, Cun Liu, Hui Zhong, Qi Yang, Jie Yu, Ping Liang

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引用次数: 1

Abstract

Introduction: The present study aimed to evaluate the influence of biological characteristics of hepatocellular carcinoma (HCC) on the Liver Imaging Reporting and Data System (LI-RADS) v2017 category of contrast-enhanced ultrasound (CEUS) in patients with high risk and compare the outcomes among different categories after radical resection.

Methods: Between June 2017 and December 2020, standardized CEUS data of liver nodules were prospectively collected from multiple centers across China. We conducted a retrospective analysis of the prospectively collected data on HCCs measuring no more than 5 cm, as diagnosed by pathology. LI-RADS categories were assigned after thorough evaluation of CEUS features. Then, CEUS LI-RADS categories and major features were compared in different differentiation, Ki-67, and microvascular invasion (MVI) statuses. Differences in recurrence-free survival (RFS) among different LI-RADS categories were further analyzed.

Results: A total of 293 HCC nodules in 293 patients were included. This study revealed significant differences in the CEUS LI-RADS category of HCCs among differentiation (p < 0.001) and levels of Ki-67 (p = 0.01) and that poor differentiation (32.7% in LR-M, 12% in LR-5, and 6.2% in LR-4) (p < 0.001) and high level of Ki-67 (median value 30%) were more frequently classified into the LR-M category, whereas well differentiation (37.5% in LR-4, 15.1% in LR-5, and 11.5% in LR-M) and low levels of Ki-67 (median value 11%) were more frequently classified into the LR-4 category. No significant differences were found between MVI and CEUS LI-RADS categories (p > 0.05). With a median follow-up of 23 months, HCCs assigned to different CEUS LI-RADS classes showed no significant differences in RFS after resection.

Conclusions: Biological characteristics of HCC, including differentiation and level of Ki-67 expression, could influence major features of CEUS and impact the CEUS LI-RADS category. HCCs in different CEUS LI-RADS categories showed no significant differences in RFS after resection.

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≤5cm肝细胞癌的造影增强超声肝脏成像报告和数据系统：生物学特征和患者预后。

引言：本研究旨在评估肝细胞癌（HCC）的生物学特征对高危患者肝脏成像报告和数据系统（LI-RADS）v2017类别超声造影（CEUS）的影响，并比较不同类别患者根治性切除后的结果。方法：在2017年6月至2020年12月期间，前瞻性地从中国多个中心收集肝结节的标准化CEUS数据。我们对前瞻性收集的病理诊断为不超过5厘米的HCC数据进行了回顾性分析。LI-RADS类别是在对CEUS特征进行彻底评估后分配的。然后，比较CEUS LI-RADS在不同分化、Ki-67和微血管侵袭（MVI）状态下的分类和主要特征。进一步分析了不同LI-RADS类别之间无复发生存率（RFS）的差异。结果：293例患者中共有293个HCC结节。本研究显示，分化（p＜0.001）和Ki-67水平（p＝0.01）的HCC的CEUS LI-RADS类别存在显著差异，而分化差（LR-M为32.7%，LR-5为12%，LR-4为6.2%）（p＜001）和Ki六十七高水平（中位值30%）更常被归类为LR-M类别，而分化良好（LR-4为37.5%，LR-5为15.1%，LR-M为11.5%）和Ki-67水平低（中位值11%）更常被归类为LR-4类。MVI和CEUS LI-RADS类别之间没有发现显著差异（p>0.05）。在中位随访23个月的情况下，分配到不同CEUS LI-LADS类别的HCC在切除后的RFS没有显示出显著差异。结论：HCC的生物学特征，包括分化和Ki-67表达水平，可能影响CEUS的主要特征，并影响CEUS LI-RADS的分类。不同CEUS LI-RADS类别的HCC切除后RFS无显著差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Liver Cancer Medicine-Oncology

CiteScore

20.80

自引率

7.20%

发文量

审稿时长

16 weeks

期刊介绍： Liver Cancer is a journal that serves the international community of researchers and clinicians by providing a platform for research results related to the causes, mechanisms, and therapy of liver cancer. It focuses on molecular carcinogenesis, prevention, surveillance, diagnosis, and treatment, including molecular targeted therapy. The journal publishes clinical and translational research in the field of liver cancer in both humans and experimental models. It publishes original and review articles and has an Impact Factor of 13.8. The journal is indexed and abstracted in various platforms including PubMed, PubMed Central, Web of Science, Science Citation Index, Science Citation Index Expanded, Google Scholar, DOAJ, Chemical Abstracts Service, Scopus, Embase, Pathway Studio, and WorldCat.