Type 2 diabetes mellitus is associated with manic morbidity in elderly patients with mood disorders.

IF 2.1 3区 医学 Q3 PHARMACOLOGY & PHARMACY
Francesco Weiss, Giulio Emilio Brancati, Camilla Elefante, Alessandra Petrucci, Teresa Gemmellaro, Lorenzo Lattanzi, Giulio Perugi
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Abstract

The association between mood disorders, especially bipolar disorder (BD), and metabolic disorders, is long known. However, to which extent metabolic disorders affect the course of mood disorders in late life is still open to inquiring. To assess the impact of type 2 diabetes mellitus (T2DM) on late-life mood disorders a retrospective chart review was performed. Elderly depressive patients (≥ 65 years) diagnosed with Major Depressive Disorder (N = 57) or BD (N = 43) and followed up for at least 18 months were included and subdivided according to the presence of T2DM comorbidity. Vascular encephalopathy (39.1% vs. 15.6%, P  = 0.021) and neurocognitive disorders (21.7% vs. 5.2%, P  = 0.028), were more frequently reported in patients with T2DM than in those without. Patients with T2DM showed a greater percentage of follow-up time in manic episodes (r = -0.23, P  = 0.020) and a higher rate of manic episode(s) during follow-up (21.7% vs. 5.2%, P  = 0.028) than those without. When restricting longitudinal analyses to patients with bipolar spectrum disorders, results were confirmed. In line with the well-known connection between BD and metabolic disorders, our data support an association between T2DM and unfavorable course of illness in the elderly with BD.

2型糖尿病与老年情绪障碍患者的躁狂发病率有关。
情绪障碍,尤其是双相情感障碍(BD)和代谢障碍之间的联系是众所周知的。然而,代谢障碍在多大程度上影响晚年情绪障碍的进程仍有待探究。为了评估2型糖尿病(T2DM)对晚年情绪障碍的影响,进行了回顾性图表审查。诊断为重度抑郁症的老年抑郁症患者(≥65岁)(N = 57)或BD(N = 43)并随访至少18个月,并根据T2DM合并症的存在进行细分。血管性脑病(39.1%对15.6%,P = 0.021)和神经认知障碍(21.7%对5.2%,P = 0.028)在T2DM患者中的报告频率高于在没有T2DM的患者中。T2DM患者躁狂发作的随访时间百分比更高(r = -0.23,P = 0.020)和随访期间较高的躁狂发作率(21.7%对5.2%,P = 0.028)。当将纵向分析局限于双相情感障碍患者时,结果得到了证实。与众所周知的BD与代谢紊乱之间的联系一致,我们的数据支持T2DM与老年BD患者的不良病程之间的关联。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.40
自引率
23.10%
发文量
97
审稿时长
>12 weeks
期刊介绍: International Clinical Psychopharmacology provides an essential link between research and clinical practice throughout psychopharmacology. It reports on studies in human subjects, both healthy volunteers and patients, which relate the effects of drugs on psychological processes. A major objective of the journal is to publish fully refereed papers which throw light on the ways in which the study of psychotropic drugs can increase our understanding of psychopharmacology. To this end the journal publishes results of early Phase I and II studies, as well as those of controlled clinical trials of psychotropic drugs in Phase II and IV. Other topics covered include the epidemiology of psychotropic drug prescribing and drug taking, the sociology of psychotropic drugs including compliance, and research into the safety and adverse effects of these compounds.
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